We examined the effect of acyl-coenzyme A:cholesterol acyltransferase (ACAT) inhibitors on intracellular cholesterol stores in primary human monocyte-derived macrophages (HMMs) during foam cell formation. HMMs were exposed to acetylated low density lipoprotein (acLDL, 500 microg protein per mL) with or without 58-035 (1 to 10 microg/mL) or CI-976 (2 microg/mL) for 2 to 48 hours. Total cholester...

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For the linear regression model Yi = x~P + fi' 1 :::; i :::; n, where f1, ..., f n are independent and identically distributed, robust tests of various hypotheses on Pare developed; by 'robust', we mean robustness of size and power against long tailed error distributions which may not be symmetric. The proposed test statistic, denoted MR, resembles the likelihood ratio statistic since, ignoring...

Cholesteryl ester accumulation in arterial wall macrophages (foam cells) is a prominent feature of atherosclerotic lesions. We have previously shown that 5774 macrophages accumulate large amounts of cholesteryl ester when incubated with unmodified low density lipoprotein (LDL) and that this is related to sluggish down-regulation of the 5774 LDL receptor and 3hydroxy-3-methylglutaryl-coenzyme A ...

Aims. An asteroseismological study of PG 1159−035, the prototype of the GW Vir variable stars, has been performed on the basis of detailed and full PG1159 evolutionary models presented by Miller Bertolami & Althaus (2006). Methods. We carried out extensive computations of adiabatic g-mode pulsation periods on PG1159 evolutionary models with stellar masses spanning the range 0.530 to 0.741M⊙. Th...

We present an imaging and spectroscopic survey of galaxies in fields around QSOs HE 0226−4110, PKS 0405−123, and PG 1216+069. The fields are selected to have ultraviolet echelle spectra available, which uncover 195 Lyα absorbers and 13 OVI absorbers along the three sightlines. We obtain robust redshifts for 1104 galaxies of rest-frame absolute magnitude MR −5log h . −16 and at projected physica...