Objective This study aimed to investigate the effects of hypoxia-inducible factor-1α (HIF-1α), factor-2α (HIF-2α), and erythroferrone (ERFE) on hepcidin in patients with chronic kidney disease (CKD) stages 3–5 renal anemia. Methods A total 90 CKD anemia were selected for at Nephrology Department Fujian Provincial People’s Hospital divided into three groups, according stage, while another 30 hea...

Hypoxia-inducible factor-1α (HIF-1α) is known as a transactivator for VEGF gene promoter. It can be induced by hypoxia. However, no study has been done so far to dissect HIF-1α-mediated effects from hypoxia or VEGF-mediated effects. By using a HIF-1α knockout (HIF-1α KO) cell system in mouse embryonic fibroblast (MEF) cells, this study analyzes cell migration and HIF-1α, hypoxia and VEGF activa...

We have previously reported on the inhibition of HIF-1α (hypoxia-inducible factor α)-regulated pathways by HEXIM1 [HMBA (hexamethylene-bis-acetamide)-inducible protein 1]. Disruption of HEXIM1 activity in a knock-in mouse model expressing a mutant HEXIM1 protein resulted in increased susceptibility to the development of mammary tumours, partly by up-regulation of VEGF (vascular endothelial grow...

Background: In the previous decade, various benefits and biological activities of royal jelly, applied in alternative modern medicine, cosmetics, have been reported. However, effects jelly extract (RJ) on keratinocytes not fully elucidated. Objective: The primary objectives this study were to reveal RJ explore underlying mechanism. Methods: HaCaT cells, an immortal human epidermis-derived kerat...

In Hashimoto’s thyroiditis (HT), oxidative stress (OS) is driven by Th1 cytokines’ response interfering with the normal function of thyrocytes. OS results from an imbalance between excessive production reactive oxygen species (ROS) and a lowering antioxidant production. Moreover, has been shown to inhibit Sirtuin 1 (SIRT1), which able prevent hypoxia-inducible factor (HIF)-1α stabilization. The...

Hypoxia-like tissue alterations, characterized by the upregulation of hypoxia-inducible factor-1α (HIF-1α), have been described in the normal appearing white matter and pre-demyelinating lesions of multiple sclerosis (MS) patients. As HIF-1α regulates the transcription of a wide set of genes involved in neuroprotection and neuroinflammation, HIF-1α expression may contribute to the pathogenesis ...

Abstract Background and Aims Mitophagy activation is crucial for hypoxia signaling in acute kidney injury (AKI). Selective removal of damaged mitochondria mediated through a concerted function coding non-coding RNA expressions. Insights on HIF-1α lncRNA-regulated mitophagy mechanism are not known. The study aims to investigate the role hypoxia-inducible factor 1α (HIF-1α) regulated long (lncRNA...

BACKGROUND Hypoxia-inducible factor 1α (HIF-1α) is an important regulator of immune and inflammatory responses. We hypothesized that nasal allergic inflammation is attenuated by HIF-1α inhibition and strengthened by HIF-1α stabilization. OBJECTIVE To elucidate the role of HIF-1α in a murine model of allergic rhinitis (AR). METHODS Mice were pretreated with the HIF-1α inhibitor 2-methoxyestr...