نتایج جستجو برای: high glucose
تعداد نتایج: 2200793 فیلتر نتایج به سال:
low glucose condition induces neuronal cell-death via intracellular mechanisms including mitogen-activated protein kinases (mapk) signaling pathways. it has been shown that low glucose medium decreases neuronal survival in cerebellar granule neurons (cgns). in this study, we have examined the activation of jnk, p38kinase and erk1/2 pathways in low glucose medium in cgns. the cgns were prepared ...
Low glucose condition induces neuronal cell-death via intracellular mechanisms including mitogen-activated protein kinases (MAPK) signaling pathways. It has been shown that low glucose medium decreases neuronal survival in cerebellar granule neurons (CGNs). In this study, we have examined the activation of JNK, p38kinase and ERK1/2 pathways in low glucose medium in CGNs. The CGNs were prepared ...
Impaired glucose tolerance has several adverse effects on growing fetus. In this study we evaluated the effect of excessive weight gain during pregnancy on the risk of glucose intolerance in pregnant women. A case-control study was conducted through which the glucose tolerance status after 100 gram oral glucose intake was compared between 60 pregnant women with maximum 10 weeks of gestation and...
Background: Clinical evidence indicates the diabetes-induced impairment of osteogenesis caused by a decrease in osteoblast activity. Flavonoids can increase the differentiation and mineralization of osteoblasts in a high-glucose state. However, some flavonoids such as luteolin may have the potential to induce cytotoxicity in osteoblast-like cells. This study was performed to investigate whether...
Objective(s): Hyperglycemia, oxidative stress and apoptosis have key roles in pathogenesis of diabetic neuropathy. There are local renin-angiotensin systems (RASs) in different tissues such as neural tissue. Local RASs are involved in physiological and pathophysiological processes such as inflammation, proliferation and apoptosis. This study aimed to investigate the role of local renin-angioten...
materials and methods: nrvms were adopted as the cell model to investigate the roles of pi3k/akt and foxo3a in mediating hyperglycemia-induced apoptosis in cardiomyocytes. annexin-v-fitc staining and pi staining were used to evaluate the apoptosis in nrvms under indicated conditions of serum starvation, high glucose exposure, and pharmacological or genetic manipulations on the expressions of pi...
introduction: g-proteins have an important role in the cell signaling of numerous receptors. the situation of g-proteins in health and disease and their critical role in the development of diabetic side effects is an interested scientific field. here, the changes in the expression of g-protein subunits (gαi, gαs and gβ) were evaluated in hyperglycemic situation of pc12 cells as a cellular model...
Background: Pre-diabetes is a high risk condition for developing type 2 diabetes mellitus and cardiovascular disease. The target of this study is evaluation of incidence rate of pre-diabetes and its risk factors in a long- term follow up in the Tehran Lipid and Glucose Study. Methods: The Tehran Lipid and Glucose Study is a prospective study being accomplished on a characteristic sample of t...
background: this study conducted as part of a screening program for the promotion of community health in the primary care setting of ormos korthi in andros, greece. the objective of this study was to identify the levels of glucose and total cholesterol in individuals without major cardiovascular problems in order to identify cases of undetected dyslipidemia and high blood glucose levels, in a r...
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