objective the hippocampal circuit integrity is crucial for learning and memory. despite the existing reports on hippocampal–dependent memory impairment due to noise stress, there are only a few studies on the effect of noise stress on anatomical structure of hippocampus. the present study is aimed to investigate the likely effects of chronic noise exposure on the volume of rat hippocampus. mate...

Neurogenesis occurs throughout life in several regions of the brain. In this lecture, a new sight for the role of the dentate gyrus and adult hippocampal neurogenesis in anxiety disorders will be discussed. The region that has obtained the most attention for its involvement in the neurogenesis of affective and anxiety disorders are the hippocampal and dentate gyrus. Evidence strongly suggests t...

Introduction: There are evidences showing the role of nitric oxide in the opiate reward properties. The role of nitric oxide signaling pathway as an intracellular mechanism on augmentation of long term potentiation in hippocampal CA1 area of rats is also confirmed. It has been also reported that oral morphine dependence facilitates formation of spatial learning and memory via activation of N...

The extraordinary navigational ability of homing pigeons provides a unique spatial cognitive system to investigate how the brain is able to represent past experiences as memory. In this paper, we first summarize a large body of lesion data in an attempt to characterize the role of the avian hippocampal formation (HF) in homing. What emerges from this analysis is the critical importance of HF fo...

Background: Hippocampal atrophy is a key pathologic and magnetic resonance imaging (MRI) feature of human Alzheimer’s disease (AD). has not been documented via MRI in canine cognitive dysfunction (CCD), which considered as the dog model AD.Aim: The purpose this retrospective comparative volumetric study was to compare total hippocampal volumes between successfully aging (control) dogs diagnosed...

background and objectives: study of deleterious effect of neurotoxins on the animals' brain is a fascinating research plan. in this project, the damage effect of colchicine on the hippocampal cornu ammonis 1 (ca1) was examined by the studying the hippocampal tissue. materials and methods: injections of colchicine (1-75 μg/rat, intra- hippocampal ca1) were performed in cannulated male wistar rat...

Objective(s):To determine the effect of acetylcholine (ACh), pilocarpine, and atropine on pain evoked responses of pain excited neurons (PEN) and pain inhibited neurons (PIN) in hippocampal CA3 region of morphine addicted rats. Materials and Methods:Female Wistar rats, weighing between 230-260 g were used in this study. Morphine addicted rats were generated by subcutaneous injection of increasi...

Hippocampal region CA2 has received increased attention due to its importance in social recognition memory. While specific function remains be identified, there are indications that plays a major role variety of situations, widely extending beyond In this targeted review, we highlight lines research which have begun converge on more fundamental for hippocampus-dependent memory processing. We di...

background: primary cultures of embryonic neurons have been used to introduce a model of neurons in physiological and pathological conditions. however, age-related cellular events limit this method as an optimal model in adult neurodegenerative diseases studies. besides, short-interval changing media in previous cultures decreases the effectiveness of this model. as an example of this matter, w...