Epilepsy as well as chronic use of most antiepileptic drugs, particularly in children, predisposes to cognitive impairment. The brain is considered abnormally sensitive to oxidative stress and damage which observed during seizure activity. Omega-3 (OM3) fatty acids are known antioxidants that play a role in nervous system activity, cognitive development, memory-related learning, and synaptic tr...

Chronic intermittent hypoxia (CIH) is a hallmark of obstructive sleep apnea (OSA), which induces hippocampal injuries mediated by oxidative stress. This study aims to examine the neuroprotective mechanism of Lycium barbarum polysaccharides (LBP) against CIH-induced spatial memory deficits. Adult Sprague-Dawley rats were exposed to hypoxic treatment resembling a severe OSA condition for a week. ...

Numerous studies have described memory deficits following sleep deprivation. There is also evidence that the absence of sleep increases brain oxidative stress. The present study investigates the effects of a pro-oxidant agent--3-nitropropionic acid (3-NP)--on hippocampal oxidative stress and passive avoidance performance of sleep-deprived mice. Mice were repeatedly treated i.p. with saline or 5...

Oxidative stress plays a major role in the pathogenesis of Alzheimer's disease (AD) of sporadic origin. The expression of DHCR24 (Seladin-1), marker for neuronal oxidative stress and degeneration, has been reported to be altered in the brains of AD patients. In the present study, we investigated the effect of trimetazidine (TMZ) on the hippocampal oxidative parameters and the expression of DHCR...

Safranal is a monoterpene aldehyde found in saffron (Crocus sativus L.) petals. It has been previously reported that safranal has a wide range of activities such as antioxidant and anti-inflammatory effects. In this study, we examined the effect of safranal on brain injuries in a transient model of focal cerebral ischemia. Transient focal cerebral ischemia was induced by middle cerebral artery ...

objective: alzheimer’s disease is the most common type of neurodegenerative disorder. it has been suggested that oxidative stress can be one of the pathological mechanisms of this disease. carnosic acid (ca) is an effective antioxidant substance and recent studies have shown that its electrophilic compounds play a role in reversing oxidative stress. thus we tried to find out whether ca administ...

This in vitro study evaluated the detrimental effect of acute gamma (γ)-irradiation on rat immature hippocampal neurons. Rat immature hippocampal neurons (0.5 day in vitro) were irradiated with 0~4 Gy γ-rays. Cytotoxicity was analyzed using a lactate dehydrogenase release assay at 24 h after γ-irradiation. Radiation-induced cytotoxicity in immature hippocampal neurons increased in a dose-depend...

cognitive deficits have been observed in patients with multiple sclerosis (ms) because of hippocampal insults. oxidative stress plays a key role in the pathophysiology of ms. the aim of this study was to evaluate the effects of crocus sativus l., commonly known as saffron, on learning and memory loss and the induction of oxidative stress in the hippocampus of toxic models of ms. one week after ...

Numerous researches supported that oxidative stress and inflammation play important roles in the development of diabetic encephalopathy (DEP). Notoginsenoside R1 (NGR1), one major component of Panax notoginseng, is believed to have anti-oxidative, anti-inflammatory and neuroprotective properties. However, its neuroprotective effects against DEP and underlying mechanisms are still unknown. In th...