The histone-like protein HU is the most-abundant DNA-binding protein in bacteria. The HU protein non-specifically binds and bends DNA as a hetero- or homodimer, and can participate in DNA supercoiling and DNA condensation. It also takes part in DNA functions such as replication, recombination, and repair. HU does not recognize any specific sequences but shows a certain degree of specificity to ...

The emergence of hybrid DNA–protein nanostructures in recent years has expanded the application DNA nanotechnology. Previous studies reported integration proteins into by sequence-dependent interactions or chemical modifications DNA, which limit design flexibility nanostructures. Here we report construction sequence-independent geometry-based using self-assembly single-stranded (ss) and histone...

The linker histones (H1 or H5) which play a key role in the folding of chromatin, are general repressors of gene expression. Nuclei of the mature chicken erythrocytes (and in some mammalian cells) contain both of them. Although the interaction of H5 with DNA is stronger than that of H1, it does not prevent the transcription of some erythroid-specific genes. It has been shown that some modificat...

A DNA-bineting protein (about lOkDa and pI>9.7) of Streptomyces lividans TK24 was purified on a denatured DNA-Cellulose column, and then on a native DNA-Cellulose column. The N-terminal amino acid sequence of this protein had high homology with those of small basic DNA-binding proteins known as histone-like proteins. Thus, this protein was designated HSI (histone-like protein of ::J.. lividans)...

Background During mammalian spermatogenesis unique and dynamic epigenetic events occur leading to chromatin condensation. Through these events, histone demethylases such as JMJD1A play important roles in compaction of sperm chromatin, due to regulation of histone methylation dynamics and alteration of chromatin structure. As �histone methylation� is one of the best-characterized modifications i...