although the majority of the patients with traumatic brain injury presents with injuries involving the extremities, there was a clear paucity of adequate experimental polytrauma models. to close this gap, we conducted several studies to establish two different polytrauma mice models including both closed and open traumatic brain injury. male c57bl mices with a mean weight of 23g were anesthetiz...

Pulmonary sarcoidosis is reported to have complication of lymphoproliferative disease such as malignant lymphoma, but the complication of multicentric Castleman's disease (MCD) is rarely reported. In our case of a 60-year-old woman, bilateral hilar lymphadenopathy was noted in her chest X-ray. We performed a transbronchial lung biopsy. She was diagnosed as having pulmonary sarcoidosis (Stage II...

background and objective: smoking can be associated with the decreasing gingival blood flow and epithelial changes. the aim of this study was to evaluate the histopathological changes of gingival epithelium and connective tissue in smokers. methods: the study was case-control. sixty male patients (28 smokers and 32 nonsmokers) suffering chronic periodontitis were participated in the study. peri...

Endobroncheal tuberculosis is defined as tuberculous infection of the tracheobronchial tree with microbial and histopathological evidence. The disease is usually mistaken for other lung diseases including lung cancer. Bronchial stenosis is a common complication of this type of tuberculosis despite the use of effective anti-tuberculous chemotherapy. We are presenting a case of endobronchial tube...

Thyroglossal sinus are a frequent clinical entity in the pediatric population, mostly present upper midline of neck. It is most common complication following thyroglossal duct cysts and well known for recurrence, if inadequately excised or infected. A careful consideration magnetic resonance imaging (MRI) pre-operatively helps improve outcomes reduces complications. We case 12-year-old boy oper...

Bullous pemphigoid is a rare complication of immune checkpoint inhibitor treatment. We report case pembrolizumab-induced bullous in patient with malignant melanoma and concomitant cutaneous squamous cell carcinoma that regressed. A 77-year-old woman metastatic 3-year history growing skin nodule on her left calf was treated pembrolizumab. Histopathological examination the established diagnosis c...

Intracardiac papillary endothelial hyperplasia is seen very rare in the literature. This report describes the case of a 65-year old male patient who had intracardiac neoplasm behind the right coronary aortic cusp. The lesion was treated successfully by surgical excision. According to histopathological analysis the diagnosis was papillary endothelial hyperplasia. The patient was discharged witho...

the modern surgical endodontic treatment is a safe and predictable procedure with high success rate. however, several factors can retard or impede the proper healing process. use of a high speed handpiece during hard tissues management (osteotomy and apical resection) can potentially be one of these factors. formation of metallic debris from the surgical diamond burs, production of necrotic loc...