We read with great interest the article in CHEST (July 2002) by Masakazu et al,1 who observed a haplotype loss of class I human leukocyte antigens (HLAs) in several newly established lung cancer cell lines and identified it as a mechanism of tumor escape from the immunosurveillance system of the host. However, as for the HLA genes of lung cancer cell lines passing for many generations, such as ...

We read with great interest the article in CHEST (July 2002) by Masakazu et al,1 who observed a haplotype loss of class I human leukocyte antigens (HLAs) in several newly established lung cancer cell lines and identified it as a mechanism of tumor escape from the immunosurveillance system of the host. However, as for the HLA genes of lung cancer cell lines passing for many generations, such as ...

OBJECTIVE Associations between human leukocyte antigens (HLA) and sarcoidosis have been reported in several studies. We aimed to investigate these associations in Turkish patients. PATIENTS AND METHOD We performed HLA-A, HLA-B, HLA-C, and HLA-D typing in 83 patients with sarcoidosis and in 250 healthy controls using a microlymphocytotoxicity method to investigate genetic susceptibility to the...

Chronic lymphocytic leukemia (CLL) is a malignant disorder of B cell origin, with low incidence in Asian populations. In this study we investigated the HLA-class I A and B allele frequencies in 87 Iranian CLL patients and 64 healthy controls using sequence specific primer-polymerase chain reaction (SSP-PCR) technique. Our results showed increased frequencies of HLA-A11:01 (p=0.02) and HLA-B35:0...

BACKGROUND To monitor the performance of histocompatibility testing laboratories, HLA proficiency survey in Korea has been conducted biannually since 1996. In this report, we summarized the results of the surveys performed in recent two years (2005-2006). METHODS A total of four proficiency surveys were performed, in which 59-61 laboratories participated. Each survey included three tests for ...

BACKGROUND HLA typing analysis is important in renal transplant patients. OBJECTIVES We made a plan to determine the most frequent HLA antigens in Iranian kidney transplant patients. PATIENTS AND METHODS In a retrospective cross sectional study, HLA patterns were defined in 512 kidney transplant recipients (67% male and 33% female) from different transplant centers of Tehran, Iran between 2...

Vaccinia virus A26 protein is an envelope protein of the intracellular mature virus (IMV) of vaccinia virus. A mutant A26 protein with a truncation of the 74 C-terminal amino acids was expressed in infected cells but failed to be incorporated into IMV (W. L. Chiu, C. L. Lin, M. H. Yang, D. L. Tzou, and W. Chang, J. Virol 81:2149-2157, 2007). Here, we demonstrate that A27 protein formed a protei...

Behçet disease (BD) is a multisystem autoinflammatory condition characterized by mucosal ulceration and predominantly neutropilic inflammation of immune privileged sites including the eye, brain, and synovial joint (1). In PNAS, Ombrello et al. analyze a combination of directly ascertained and imputated single nucleotide polymorphisms (SNPs) in the HLA-B region in Turkish patients with BD (2). ...