Background & Objective: Unexplained recurrent spontaneous abortion (URSA) is defined as an unknown cause of occurrence of three or more clinically detectable pregnancy losses before 20 weeks of gestation, but it occurs presumably as a result of the immune system dysfunctions. We supposed that the disruption of semen or spermatozoa might be responsible for the dysfunction of the...

Abstract Rationale: Increases in the number and size of lymphoid follicles (LFs) are present severe stages COPD have not been fully characterized. HLA complex is crucial enabling immune system to recognize “self” versus “non-self” antigens plays a major role responses cigarette smoke exposure. Methods: Lung from patients with milder (GOLD I–II) more III–IV) were sampled using GeoMX® Digital Spa...

the immune response to hepatitis b surface antigen (hbsag) is influenced by several factors, of which hla antigens and balanced secretion of th1/th2 cytokines play important roles. the aim of this study was to evaluate the influence of hla antigens on cytokine secretion by hbsag-stimulated peripheral blood mononuclear cells (pbmc) from healthy neonates vaccinated with recombinant hbsag. pbmcs w...

selective iga deficiency (igad) (serum iga concentration of pcr was used to type hla b, dr, and dq alleles in 29 iranian individuals with igad and 299 swedish individuals with igad. the results indicate a strong association with the hla b14, dr1 alleles in iranian subjects and hla b8, b12, b13, b14, b40, dr1, dr3, dr7, dq2 and dq5 alleles in swedish subjects. differences in hla association of i...

Background: In addition to Human Leukocyte Antigens (HLA) compatibility, gene polymorphisms in cytokines might also be important in the quality of allogeneic immune response. Objective: To evaluate the influence of HLA-DR matching and a number of cytokine gene polymorphisms on acute rejection after living-unrelated donor (LURD) kidney transplantation. Methods: A total of 42 renal transplants pe...

Background: Hepatitis B is an important infectious disease.  Since several years ago, mass vaccination against this viral infection has become as part of routine vaccination schedule of Iran.  However, some healthy neonates, children and adults fail to generate a protective antibody response after vaccination.Objectives: To investigate distribution of HLA class-I and class-II antigens in health...

Introduction: Pigeon Breeder’s Pneumonitis (PBP) results due to a complex pathophysiology that includes exposure avian antigens. Susceptibility has been linked human leukocyte antigen (HLA) class II, though consensus not reached. The goal of this systematic review is further elucidate the association between PBP and HLA-DR subtypes.

In addition to ultrasonographic monitoring of folliculogenesis, urinary luteinizing hormone testing, luteal phase endometrial biopsy, serum antiphospholipid antibodies, etc., immunologic tests are recently being used to evaluate reproductive disorders. In this study, sharing of HLA-A, B, C and DR antigens and the presence of antipaternal cytotoxic antibody (APCA) was assessed using microcyt...

Minor histocompatibility antigens (MiHAs) are polymorphic peptides on the cell surface derived from self-proteins that capable to induce an immune response during allogeneic hematopoietic stem cells transplantation. Their presentation occurs in context of certain major complex (HLA – human leucocyte antigen) alleles. One most common HLA alleles is HLA-A*02:01. Accordingly, for a significant num...