introduction: elevated plasma total homocysteine is an independent risk factor for cardiovascular disease and a sensitive marker of vitamin b12 and folate insufficiency. folate and vitamin b12 have a protective effect on cardiovascular disease. this effect may be partly explained by mechanisms independent of homocysteine. this survey is the first population based study to evaluate the plasma to...

Recent studies have documented the importance of lipids and lipoproteins as determinants of serum total homocysteine concentrations in persons with myocardial infarction, and in healthy subjects. Associations between various biological systems and total homocysteine have also been reported. However, some of these associations are poorly understood. The purpose of our study was to measure serum ...

background: coronary artery disease (cad) is emerging as a major public health concern in most developing countries. during the past 10 years, the vast majority of over 100 case-control retrospective studies have shown that elevated plasma homocysteine level is a strong independent risk factor for coronary artery disease. methylenetetrahydrofolate reductase (mthfr) is a key enzyme in folate and...

Homocysteine is a chemical in the blood that is produced when an amino acid (a building block of protein) called methionine is broken down in the body. We all have some homocysteine in our blood. Elevated homocysteine levels (also called hyperhomocysteinemia) may cause irritation of the blood vessels. Elevated levels of homocysteine show an increased risk for (1) hardening of the arteries (athe...

OBJECTIVE To determine the size of reduction in homocysteine concentrations produced by dietary supplementation with folic acid and with vitamins B-12 or B-6. DESIGN Meta-analysis of randomised controlled trials that assessed the effects of folic acid based supplements on blood homocysteine concentrations. Multivariate regression analysis was used to determine the effects on homocysteine conc...

Introduction. Homocysteine is an amino acid that formed in the metabolism of methionine as quantitatively most important metabolite. Its chemical structure has been known for 90 years and its biological roles are still being investigated. Under normal conditions, homocysteine present plasma at concentration 5 - 9 mmol/l. When cell capacity reached, it transported to extracellular space, until i...

OBJECTIVES Even though several epidemiological studies have observed positive associations between blood lead levels and homocysteine, no study has examined whether this association differs by the levels of micronutrients, such as folate, vitamin B6, and vitamin B12, which are involved in the metabolism of homocysteine. In this study, we examined the interactions between micronutrients and bloo...

Aim: In this study, we evaluated the clinical and laboratory data of healthy children with vitamin B12 deficiency. The benefits methylmalonic acid (MMA) homocysteine levels difficulties encountered in diagnosing deficiency were pointed out. 
 Materials Methods: A total 70 whose serum cobalamin below 126.5 pg/ml included study. age, gender, B12, urine MMA, plasma homocysteine, white blood c...

objective: polycystic ovary syndrome (pcos) is one of the most common endocrine disorders in women. metformin is a biguanide commonly used to improve pcos symptoms. effect of metformin on the levels of serum homocysteine (hcy) in pcos women is unclear. the aim of this study is evaluating the effect of metformin administration on serum hcy levels and metabolic parameters of pcos patients. materi...