Rutin is a well-known antioxidant from the group of flavonoids. Its use in cosmetic dermal products is, however, limited due to its poor water solubility. In order to increase rutin saturation solubility and improve the diffusion to the skin, rutin nanocrystals were produced by the smartCrystal process, e.g., bead milling followed by high pressure homogenization. Rutin nanocrystals were further...

The aim of this study was to compare the production of nanocrystals of a poorly watersoluble antioxidant, quercetin, by top-down and bottom-up techniques. The top-down method used was high pressure homogenization (HPH) and bottom-up method of evaporative precipitation of nanosuspension (EPN) was used and the products from both these methods were compared. The particle size of the original drug ...

Cellulose nanocrystals (CNCs) have attracted significant interest in different industrial sectors. Many applications been developed and more are being explored. Pre-treatment of the suspension plays a critical role for applications. In this study, pre-treatment methods, including homogenization, ultrasonication, mixing with magnetic stirrer were applied to CNC suspension. After treatment, rheol...

This communication describes a facile and mild chemical etching method for resizing of CdTe nanocrystals, which provides a possible approach for tailoring the size-dependent properties of the nanocrystals.

nowadays the use of probiotic products especially yogurt, due to having wonderful and health properties, has become popular in the world. in this study, the effect of homogenization pressure (100, 150 and 200 bars) and stage (single and two) on the amount of lactic and acetic acids was investigated. yoghurts were manufactured from low-fat milk treated using high pressure homogenization at 100,1...

ZnO and ZnO: Mn nanocrystals were synthesized via reverse micelle method. The structural properties of nanocrystals were investigated by XRD. The XRD results indicated that the synthesized nanocrystals had a pure wurtzite (hexagonal phase) structure. Resistive gas sensors were fabricated by providing ohmic contacts on the tablet obtained from compressed nanocrystals powder and the installation ...

zno and zno: mn nanocrystals were synthesized via reverse micelle method. the structural properties of nanocrystals were investigated by xrd. the xrd results indicated that the synthesized nanocrystals had a pure wurtzite (hexagonal phase) structure. resistive gas sensors were fabricated by providing ohmic contacts on the tablet obtained from compressed nanocrystals powder and the installation ...

The objective of this study was to prepare baicalin solid nanocrystals (BCN-SNS) to enhance oral bioavailability of baicalin. A Box-Behnken design approach was used for process optimization. The physicochemical properties and pharmacokinetics of the optimal BCN-SNS were investigated. Multiple linear regression analysis for process optimization revealed that the fine BCN-SNS was obtained wherein...

Atorvastatin calcium, the lipid lowering agent, is taken as a model drug characterized by poor water solubility and bioavailability. In this study an attempt was made for preparation of nanocrystals using high pressure homogenization. A number of stabilizers were included as well as polymers at different concentrations, and the formulations were homogenized for ten cycles at a pressure of 1000 ...

Nanosizing is a suitable method to enhance the dissolution rate and therefore the bioavailability of poorly soluble drugs. The success of the particle size reduction processes depends on critical factors such as the employed technology, equipment, and drug physicochemical properties. High pressure homogenization and wet bead milling are standard comminution techniques that have been already emp...