The present investigation was focused to formulate semi-solid capsules (SSCs) of hydrophobic drug telmisartan (TLMS) by encapsulating semi-solid matrix of its solid dispersion (SD) in HPMC capsules. The combinational approach was used to reduce the lag time in drug release and improvise its dissolution. SDs of TLMS was prepared using hot fusion method by varying the combinations of Pluronic-F68...

This Part II paper describes the disintegration and dissolution aspects of the qualification of a new hypromellose capsule (HPMC Shell 2). This new capsule does not contain any gelling agent, and is manufactured by a thermal gelation process. Rupture time of the carrageenan-containing capsule (HPMC Shell 1) and HPMC Shell 2, as measured by an improved real-time detection method, showed only sli...

PURPOSE In vitro disintegration and dissolution are routine methods used to assess the performance and quality of oral dosage forms. The purpose of the current work was to determine the potential for interaction between capsule shell material and a green tea extract and the impact it can have on the release. METHODS A green tea extract was formulated into simple powder-in-capsule formulations...

727 Abstract: The gelatin cap-sule shell may be soft or hard depending on their formulation. Capsules are intended to be swallowed whole by the patient. In instances where patients (especially children) are unable to swallow capsules, the contents of the capsule can be removed and added (e.g., sprinkled) on soft food immediately before ingestion. In the manufacture of pharmaceuticals, encapsula...

Department of Pharmaceutics, Department of Phytopharmacy and Pharmacognosy, JSS College of Pharmacy, Udhagamandalam-643001, Tamil Nadu, India Abstract The objective of present work was to prepare a dual release drug delivery systems comprising fast and delayed release pattern using solid dispersion and pellets of the aceclofenac to achieve a desired in vitro and in vivo profile. Aceclofenac sol...

Owing to broad advantages like self-medication, unit dosage form, and patient compliance, cost effective, limited interaction with the excipients possibility of mask unpleasant taste, capsules are most extensively recognized conventional solid form after Tablet. In world Novel drug delivery system overcome disadvantages modifications made in capsule develop a product higher selectivity for medi...

Background: Prednisolone (PRD) is orally prescribed for inflammatory bowel syndrome (IBS) as the upper GIT main site of absorption; therefore, long-term PRD dosing decreases therapeutic effectiveness through systemic side effects. Objective: This work focused on formulating sustained-release alginate beads a multiparticulate system colon targeting using prednisolone to be filled in an HPMC caps...

BACKGROUND Fenoprofen calcium dehydrate (FCD) is counted as a non-steroidal, anti-inflammatory, anti-arthritic drug. FCD is slightly water soluble. It is indicated for mild pain relief, where the suggested dosage is 200 mg orally every 4 to 6 h. AIM Reduce dissolution efficiency, reach an extended therapeutic effect and reduce the frequency of the drug side effects. METHOD Combination of th...