BACKGROUND The effect of Helicobacter-pylori eradication therapy on the platelet counts in patients with immune thrombocytopenia is still debatable. The aim of this study was to assess the response rates of standard triple eradication therapy in secondary immune thrombocytopenia with Helicobacter pylori infection. METHODS From January 2012 to December 2013, 197 patients were diagnosed to have...

background treatment of helicobacter pylori (h. pylori) as a major cause of gastric diseases is of utmost concern.we aimed to assess efficacy of triple therapy (amoxicillin, clarithromycin and pantoprazole) plus probiotic yogurt (py) on eradication of h.pylori. methods total 102 h. pylori positive patients were divided to 3 groups equally and randomly. for treatment of each group amoxicillin, c...

Several studies have indicated that platelet recovery occurs in a subgroup of immune thrombocytopenia (ITP) patients after successful Helicobacter pylori (H pylori) eradication. Interestingly, a higher response rate to H pylori eradication therapy has been reported in Japan and Italy than in the United States and European countries other than Italy, suggesting that the efficacy of H pylori erad...

IMPORTANCE Helicobacter pylori colonization contributes significantly to multiple disease states, but its role in the development of tonsillar infection is unclear. Understanding the causes of chronic tonsillitis is important in clinical decision making of this commonly treated disease. OBJECTIVE To assess the correlation between H pylori colonization of tonsillar tissue in chronic tonsilliti...

Aims: To test whether a hypoacidic environment may potentially "stress" Helicobacter pylori DNA, encouraging the emergence of strain variation. Methods: This hypothesis was tested by inducing prolonged hypoacidity with omeprazole, a potent antisecretory drug. The genomic DNA ofHpylori was studied by electrophoretic separation of restriction endonuclease fragments followed by rRNA gene hybridisa...

Infection of the stomach and proximal duodenum with Helicobacter pylori induces inflammation with associated changes in the mucosa. Alterations in mucus structure and function, surface epithelial cell integrity, mucosal blood flow, and local mucosal neural and hormonal status have been observed following this infection. A proportion of subjects infected with H pylori develop duodenal ulcer dise...

Gastrointestinal diseases are one of the most frequent disorders affecting world population. They are considered among the group of first cause of dead, including colorectal and gastric cancer. Gastritis is one of the most common disease between gastrointestinal disorders and its ethiology is multifactorial, including bacterial origen as Helicobacter pylori, Echericha coli, Salmonella, non-ster...

Plasminogen activator inhibitor (PAI-)1 is associated with cancer progression, fibrosis and thrombosis. It is expressed in the stomach but the mechanisms controlling its expression there, and its biological role, are uncertain. We sought to define the role of gastrin in regulating PAI-1 expression and to determine the relevance for gastrin-stimulated cell migration and invasion. In gastric biop...