Two peptides rich in hydrophobic amino acids have and homogenates of various rat tissues. This suggests that a been isolated from venom sacs of the Europehornet, function of mastoparans and melittin is to facilitate phosphoVeSpU CrUbrO. One peptide (P-2) is structurally and lipases of both venom and victims. functionally related to the tetradwapeptide mastoWe now report the isolation and charac...

The Ppd-A1 genotype of 240 Japanese wheat cultivars and 40 foreign cultivars was determined using a PCR-based method. Among Japanese cultivars, only 12 cultivars, all of which were Hokkaido winter wheat, carried the Ppd-A1a allele, while this allele was not found in Hokkaido spring wheat cultivars or Tohoku-Kyushu cultivars. Cultivars with a photoperiod-insensitive allele headed 6.9-9.8 days ea...

Ephrins are ligands for the Eph receptor tyrosine kinases, which play important roles in patterning nervous and vascular systems. Ephrin-A1 is a glycosylphosphatidylinositol-anchored ligand that binds to the EphA receptor tyrosine kinases. In the present study, we have identified a new ephrin-A1 isoform, denoted ephrin-A1b (ephrin-A1 isoform b). Compared with the originally described ephrin-A1 ...

To understand the molecular basis of state-dependent pharmacological blockade of voltage-gated Ca channels, we systematically characterized phenylalkylamine and benzothiazepine inhibition of three molecular classes of Ca channels (a1C, a1A, and a1E) expressed from cDNA clones transfected into HEK 293 cells. State-dependent blockade figures importantly in the therapeutically desirable property o...

Two subspecies of Francisella tularensis are recognized: F. tularensis subsp. tularensis (type A) and F. tularensis subsp. holartica (type B). Type A has been subdivided further into A1a, A1b, and A2, which differ geographically and clinically. The aim of this work was to determine whether or not differences among subspecies and clades translate into distinct ecological niches. We used 223 isol...

S. B. Yuste* and Katja Lindenberg Department of Chemistry and Biochemistry 0340, University of California San Diego, La Jolla, California 92093-0340 (Received 2 April 2001; published 24 August 2001) We consider the coagulation dynamics A 1 A ! A and A 1 A % A and the annihilation dynamics A 1 A ! 0 for particles moving subdiffusively in one dimension. This scenario combines the “anomalous kinet...

In the present study, we tested whether the a1A subunit, which encodes a neuronal isoform of voltage-dependent Ca channels (VDCCs) (P-/Q-type), was present and functional in vascular smooth muscle and renal resistance vessels. By reverse transcription–polymerase chain reaction and Southern blotting analysis, mRNA encoding the a1A subunit was detected in microdissected rat preglomerular vessels ...

Transactivation of epidermal growth factor receptor (EGFR) by a1adrenoceptor (a1-AR) is implicated in contraction and hypertrophy of vascular smooth muscle (VSM). We examine whether all a1-AR subtypes transactivate EGFR and explore the mechanism of transactivation. Chinese hamster ovary (CHO) cells stably expressing one subtype of a1-AR were transiently transfected with EGFR. The transactivatio...

Alternative Mechanisms Rationale/Arguments/ Assumptions Connected Literature/Theory Resulting (Possible) Effect Support for/Against A1. Based on WTP and Exposure Theory A1a Light user segments (who are likely to have low WTP) are more likely to reduce (or even discontinue in extreme cases) their consumption of NYT content after the paywall implementation. Utility theory — WTP (Danaher 2002) Jux...

. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Functional analysis of a novel anta...