HSR-903 is a newly synthesized quinolone antibacterial agent with low toxicity. The biliary and urinary excretion of unchanged HSR-903, its R-isomer, and their glucuronides was determined after iv bolus administration (5 mg/kg) to normal Sprague-Dawley rats (SDR) and Eisai hyperbilirubinemic mutant rats (EHBR). The values for the biliary excretion clearance of HSR-903 and its glucuronide in EHB...

BACKGROUND/AIMS We established a cynomolgus macaque model of stress-induced amenorrhea in which the application of combined metabolic and psychosocial stress suppressed ovulation in stress-sensitive (SS) individuals, but not in highly stress-resilient (HSR) individuals. We previously reported that SS monkeys have deficits in global serotonin release and serotonin-related gene expression in the ...

The distribution of HSR-903, a new quinolone antibacterial agent, to the brain after i.v. administration to rats was low compared with that to other tissues. The blood-brain barrier permeability to HSR-903 determined by the brain perfusion method was low, and increased nonlinearly with increasing concentration of HSR-903 in the perfusate. When the brain-to-plasma concentration ratio (Kp, brain)...

Microstructural observations and compressive property datasets of metal matrix syntactic foam core sandwich composite at quasi-static and high strain rate (HSR) conditions (525-845 s(-1)) are provided. The data supplied in this article includes sample preparation procedure prior to scanning electron and optical microscopy as well as the micrographs. The data used to construct the stress-strain ...

AIM This study was performed to assess the contribution of the width of the anechogenous lumen of the great saphenous vein (GSV) in the groin measured by ultrasound (US) to the diagnostics of haemodynamically significant reflux (HSR) in the sapheno-femoral junction (SFJ). METHODS We examined 200 lower limbs with primary varicose veins in 182 patients. Duplex scanning was performed with the pa...

This contribution relates to the ENTER.HUB project implemented between 2012 and 2015 in the framework of the European URBACT II programme. ENTER.HUB involved twelve medium-sized cities fitting into Trans-European Transport Networks (TENT-T) corridors, realizing or forecasting a High Speed Railway (HSR) Hub and planning multimodal interfaces of regional relevance. The ENTER.HUB project questione...

Interpretive, front-of-pack (FOP) nutrition labels may encourage reformulation of packaged foods. We aimed to evaluate the effects of the Health Star Rating (HSR), a new voluntary interpretive FOP labelling system, on food reformulation in New Zealand. Annual surveys of packaged food and beverage labelling and composition were undertaken in supermarkets before and after adoption of HSR i.e., 20...

PURPOSE The purpose of this study was to investigate the influence of multiple games on exercise intensity during a world-class hockey tournament. METHODS 15 players (mean±SD age 27±4 y, stature 179±5 cm, body mass 77±5 kg, and estimated VO2 64.2±3.1 mL·kg(-1)·min(-1)) competing in the Champions Trophy (CT). Global-positioning systems assessed total distance (TD), low-speed activity (LSA; 0.1...

In this paper, we characterise tourists most likely to visit a coastal destination by high-speed rail (HSR). Our data came from a survey conducted among HSR passengers during 2014's high season (July and August) at Spain's Camp de Tarragona and Alicante Stations, each of which is near a mass tourism destination on the Mediterranean coast: the Costa Daurada and the Costa Blanca, respectively. We...