Background—Hypertonic saline (HTS) has been previously demonstrated to have immune modulatory and vascular protective effects. We assessed the effect of donor pretreatment with HTS on allograft preservation in a porcine model of orthotopic heart transplantation. Methods and Results—Orthotopic transplants were performed after 6 hours of cold static allograft storage. Donor pigs were randomly ass...

High temperature superconducting (HTS) cables are drawing attention as transmission and distribution cables in future grid, and related researches on HTS cables have been conducted actively. As HTS cables have come to the demonstration stage, failures of cooling systems inducing quench phenomenon of the HTS cables have become significant. Several diagnosis of the HTS cables have been developed ...

MOTIVATION High-throughput screening (HTS) plays a central role in modern drug discovery, allowing for testing of >100,000 compounds per screen. The aim of our work was to develop and implement methods for minimizing the impact of systematic error in the analysis of HTS data. To the best of our knowledge, two new data correction methods included in HTS-Corrector are not available in any existin...

High-throughput sequencing (HTS) technologies generate millions of sequence reads from DNA/RNA molecules rapidly and cost-effectively, enabling single investigator laboratories to address a variety of 'omics' questions in nonmodel organisms, fundamentally changing the way genomic approaches are used to advance biological research. One major challenge posed by HTS is the complexity and difficult...

Thymidylate synthase (TS) is a well-validated target for the therapy of adult cancers. Propane-1,3-diphosphonic acid (PDPA) has significant inhibitory properties against human thymidylate synthase (hTS) relative to mouse TS which is not predicted to adopt an inactive conformer. The current research aims to identify novel, lead inhibitors of hTS and examine the prediction that they bind selectiv...

This paper reports results of the test of HTS conductor manufactured by Intermagnetics General Corporation (IGC). The HTS version of the CESR dual bore quadrupole magnet has been analyzed using data obtained in this test. 1 HTS test The main purpose of the experiments described below was to obtain HTS characteristics needed for magnet design. The prime goal was to measure the HTS performance de...

High Tc superconducting (HTS) cables and their application to develop a DC power transmission system with substantial advantages have been studied. Technical analysis of the HTS DC electrical power transmission system behaviours have been carried out with the HTS DC cable technology employed and the system models built. Index Terms -High Temperature Superconductor (HTS), HTS Cable, DC Transmiss...

This paper reports results of the test of HTS conductor manufactured by Intermagnetics General Corporation (IGC). The HTS version of the CESR dual bore quadrupole magnet has been analyzed using data obtained in this test. 1 HTS test The main purpose of the experiments described below was to obtain HTS characteristics needed for magnet design. The prime goal was to measure the HTS performance de...

The increasing utilization of high-throughput screening (HTS) in toxicity studies of engineered nano-materials (ENMs) requires tools for rapid and reliable processing and analyses of large HTS datasets. In order to meet this need, a web-based platform for HTS data analyses tools (HDAT) was developed that provides statistical methods suitable for ENM toxicity data. As a publicly available comput...

BACKGROUND Musculoskeletal atrophy is one of the major problems of extended periods of exposure to weightlessness such as on the International Space Station (ISS). We developed the Hybrid Training System (HTS) to maintain an astronaut's musculoskeletal system using an electrically stimulated antagonist to resist the volitional contraction of the agonist instead of gravity. The present study ass...