Abstract Background Inflammation is believed to influence human colorectal carcinogenesis and may have an impact on prognosis survival. The mucosal immunophenotype in dogs with cancer poorly described. aim of this study was investigate whether the density, distribution grade tumor-infiltrating immune cells (TIIs) are different normal colonic tissue vs benign stages (adenomas) malignant (adenoca...

BACKGROUND Mucosa-associated Escherichia coli are frequently found in the colonic mucosa of patients with colorectal adenocarcinoma, but rarely in healthy controls. Chronic mucosal E. coli infection has therefore been linked to colonic tumourigenesis. E. coli strains carrying eae (encoding the bacterial adhesion protein intimin) attach intimately to the intestinal mucosa and are classed as atta...

The gastrointestinal tract is the most common site for malakoplakia outside the urinary tract. A variety of conditions co-exists with malakoplakia including inflammatory bowel disease, systemic lupus erythematosus, immunodeficiency and tuberculosis. Rarely, it is associated with colonic adenocarcinoma or adenomas. We report a case of malakoplakia in association with colonic adenocarcinoma.

background: radiotherapy is one of the most important factors which results in negative effects on wound healing and increases anastomosis leakage. diverting loop ileostomy has been usually performed after colorectal anastomosis in cases of colorectal cancer with a history of neoadjuvant radiotherapy to decrease the chance of leakage. considering the side effects of diverting loop ileostomy, th...

The S100A4 gene (also known as pEL98/mts1/p9Ka/18A2/42A/calvasculin /FSP1/CAPL) encoding an S100-related calcium-binding protein is implied to be involved in the invasion and metastasis of murine tumor cells. In the present study, the expression of S100A4 in human colorectal adenocarcinoma cell lines (SW837, LoVo, DLD-1, HT-29, SW480, SW620, WiDr, and Colo201) and surgically resected neoplastic...

BACKGROUND Aberrant Rad51 expression is implicated in the progression of human malignancies. However, the role of Rad51 in colorectal cancer (CRC) remains undefined. This study aimed to establish a relationship between Rad51 and clinicopathologic features of CRC. METHODS We retrospectively examined the paraffin-embedded tissue samples obtained from 54 patients with CRC who had received surgic...

Oncology guidelines currently recommend against performing colonoscopies in the workup of adenocarcinoma of unknown primary unless colonic malignancy is otherwise suggested by clinical signs or symptoms. We present 2 cases of metastatic colonic adenocarcinoma that presented only with neurologic symptoms from vertebral metastasis. Although bony metastases are a rare presentation of colon cancer ...

Dear Editor, Cutaneous metastases of adenocarcinoma are uncommon but important. The occurrence of cutaneous metastases typically signifi es widespread disease with poor prognosis. Such metastases usually occur as an isolated and rapidly growing mobile nodule unrelated topographically to the primary tumour site.1 We report a case of metastatic colonic adenocarcinoma with unusual cutaneous presen...