High morbidity and mortality of influenza virus infection makes it an important disease world-wide. Mouse is a very well-studied animal model for this disease with similar manifestation to human disease. It would be desirable to induce mucosal as well as circulating immune responses to obtain protection from infection and to decrease the spread of the virus. Cell mediated immunity (proliferativ...

BACKGROUND The mechanisms through which allergies can be inhibited after preconception immunization with allergens are not fully understood. We aimed to evaluate whether maternal immunization can induce a regulatory B (B10) cell population in offspring in concert with allergy inhibition. METHODS C57BL/6 females were or were not immunized with OVA and were mated with normal WT males. Their off...

high morbidity and mortality of influenza virus infection makes it an important disease world-wide. mouse is a very well-studied animal model for this disease with similar manifestation to human disease. it would be desirable to induce mucosal as well as circulating immune responses to obtain protection from infection and to decrease the spread of the virus. cell mediated immunity (proliferativ...

We have examined the ability of mice with severe combined immunodeficiency (SCID mice) reconstituted with human peripheral blood mononuclear cells (PBMC) to generate human antibody responses after specific immunization. SCID mice reconstituted with cells from a keyhole limpet hemocyanin (KLH)-naive donor are unable to generate specific human antibody responses after immunization with that antig...

BACKGROUND Zaire ebolavirus (ZEBOV) produces a lethal viral hemorrhagic fever in humans and non-human primates. METHODOLOGY/PRINCIPAL FINDINGS We demonstrate that the VSVDeltaG/ZEBOVGP vaccine given 28 days pre-challenge either intranasally (IN), orally (OR), or intramuscularly (IM) protects non-human primates against a lethal systemic challenge of ZEBOV, and induces cellular and humoral immu...

Brucellosis of sheep is an important way to cause human infection. Immunization effective measure for the prevention and control brucellosis sheep. Now, M5 S2 strains vaccines are commonly used immunize sheep, while live vaccines, which easy infection epidemic personnel during process. Because worried that they will be infected with due immunization it difficult promote against brucellosis, In ...

BACKGROUND Georgia's health care system underwent dramatic reform after gaining independence in 1991. The decentralization of the health care system was one of the core elements of health care reform but reports suggest that human resource management issues were overlooked. The Georgian national immunization program was affected by these reforms and is not functioning at optimum levels. This pa...