نتایج جستجو برای: hv1 regiona

تعداد نتایج: 296  

Journal: :Molecular pharmacology 2016
Audry Fernández Amaury Pupo Karel Mena-Ulecia Carlos Gonzalez

The pharmacological modulation of the immunosuppressive tumor microenvironment has emerged as a relevant component for cancer therapy. Several approaches aiming to deplete innate and adaptive suppressive populations, to circumvent the impairment in antigen presentation, and to ultimately increase the frequency of activated tumor-specific T cells are currently being explored. In this review, we ...

2016
Aaron L Randolph Younes Mokrab Ashley L Bennett Mark Sp Sansom Ian Scott Ramsey

The Hv1 proton channel is evidently unique among voltage sensor domain proteins in mediating an intrinsic 'aqueous' H+ conductance (GAQ). Mutation of a highly conserved 'gating charge' residue in the S4 helix (R1H) confers a resting-state H+ 'shuttle' conductance (GSH) in VGCs and Ci VSP, and we now report that R1H is sufficient to reconstitute GSH in Hv1 without abrogating GAQ. Second-site mut...

Journal: :Biophysical journal 2014
Carlos A Villalba-Galea

The voltage sensing domain (VSD) of the voltage-gated proton channel Hv1 mediates a H(+)-selective conductance that is coordinately controlled by the membrane potential (V) and the transmembrane pH gradient (ΔpH). Allosteric control of Hv1 channel opening by ΔpH (V-ΔpH coupling) is manifested by a characteristic shift of approximately 40 mV per ΔpH unit in the activation. To further understand ...

Journal: :Journal of neurochemistry 2015
Junli Liu Daishi Tian Madhuvika Murugan Ukpong B Eyo Cheryl F Dreyfus Wei Wang Long-Jun Wu

NADPH oxidase (NOX)-dependent reactive oxygen species (ROS) production in inflammatory cells including microglia plays an important role in demyelination and free radical-mediated tissue injury in multiple sclerosis (MS). However, the mechanism underlying microglial ROS production and demyelination remains largely unknown. The voltage-gated proton channel, Hv1, is selectively expressed in micro...

Journal: :Hypertension 2014
Chunhua Jin Jingping Sun Carly A Stilphen Susan M E Smith Hiram Ocasio Brent Bermingham Sandip Darji Avirup Guha Roshan Patel Aron M Geurts Howard J Jacob Nevin A Lambert Paul M O'Connor

We previously characterized a H(+) transport pathway in medullary thick ascending limb nephron segments that when activated stimulated the production of superoxide by nicotinamide adenine dinucleotide phosphate oxidase. Importantly, the activity of this pathway was greater in Dahl salt-sensitive rats than salt-resistant (SS.13(BN)) rats, and superoxide production was enhanced in low Na(+) media...

Journal: :Molecular and cellular endocrinology 2012
Antoun El Chemaly Nicolas Demaurex

Recent work on animal models has revealed the important role played by the voltage-gated proton channel Hv1 during bacterial killing by innate immune cells. Studies from mice lacking Hv1 channels showed that Hv1 proton channels are required for high-level production of reactive oxygen species (ROS) by the NADPH oxidase of phagocytes (NOX2) in two ways. First, Hv1 channels maintain a physiologic...

2016
Thomas E DeCoursey Deri Morgan Boris Musset Vladimir V Cherny

The voltage-gated proton channel (HV1) is a widely distributed, proton-specific ion channel with unique properties. Since 2006, when genes for HV1 were identified, a vast array of mutations have been generated and characterized. Accessing this potentially useful resource is hindered, however, by the sheer number of mutations and interspecies differences in amino acid numbering. This review orga...

Journal: :The Journal of Cell Biology 1984
D Wenkert C D Allis

Vegetative cells of the ciliated protozoan Tetrahymena thermophila contain a transcriptionally active macronucleus and a transcriptionally inactive micronucleus. Earlier studies ( Allis , C. D., C. V. C. Glover , J. K. Bowen, and M. A. Gorovsky , 1980, Cell, 20:609-617; and Allis , C. D., Y. S. Ziegler , M. A. Gorovsky , and J. B. Olmsted, 1982, Cell, 31:131-136) demonstrated the existence of a...

2016
Jie Li

[2]Research Progress(10.5 points) In this project, we investigated the role of Nand C-terminal domain of human voltage-gated proton channel Hv1 in the gating mechanism using fluorescence technology. The plan in details is as follows: (1) To determine the interaction between Nand C-terminal domains, the N-terminal domain was cloned, expressed and purified. (2) The interaction between Nand C-term...

2015
Brittany M. Ott Lidia Beka Joerg Graf Rita V. M. Rio

The Pedobacter sp. Hv1 strain was isolated from the medicinal leech, Hirudo verbana, mucosal castings. These mucosal sheds have been demonstrated to play a role in horizontal symbiont transmission. Here, we report the draft 4.9 Mbp genome sequence of Pedobacter sp. strain Hv1.

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