INTRODUCTION Health care professionals are constantly seeking novel approaches to treat pressure ulcers because of the impact they have on patient quality of life and health, as well as the costs associated with treating them. METHODS A review of the literature from 2002-2012 was conducted on the clinical usefulness of hyaluronic acid in tissue regeneration. Reports suggest that the therapeut...

3 The abbreviations used are: ROS, reactive oxygen species; VSMC, vascular smooth muscle cells, HA, hyaluronic acid; DMEM, Dulbecco’s modified Eagle’s medium; FBS, fetal bovine serum; Has2, hyaluronan synthase 2; Hyal3, hyaluronidase 3; LMW-HA, low-molecular-weight HA; HMW-HA, highmolecular-weight HA; DPI, diphenyleneiodonium chloride; DMNQ, 2,3-Dimethoxy-1,4-naphthoquinone; GKT136901 (2-(2-chl...

Objective To evaluate the efficacy of intra-articular viscosupplementation therapy with hyaluronic acid for pain relief of knee osteoarthritis, we conducted a meta-analysis of randomized, doubleblinded, placebo-controlled trials. Methods We searched systematically for randomized, double-blinded, placebo-controlled trials of hyaluronic acid (hyaluronan and hylan G-F20) for pain relief of knee os...

Objetive:The degenerative diseases of the tempo-romandibular joint (TMJ) are characterized by a progressive destruction articular tissues condyle and glenoid fossa. The main aim this review is to describe effectiveness hyaluronic acid (HA) in treatment TMJ accordance with available scientific evidence. Material Methods: A literature search was made following databases EBSCO, Pubmed, Cochrane Tr...

INTRODUCTION Clinical trials provided controversial results on whether the injection of hyaluronan preparations into osteoarthritic joints reduces pain. Problems of clinical studies may be the substantial placebo effects of intra-articular injections, different severity and rate of progression of the disease and others. We hypothesize that the use of preclinical pain models may help to clarify ...

Background: Hyaluronic acids act upon keratinocytes via CD44 receptors and regulate proliferation and differentiation. Some cosmetic hyaluronan lotions manufactured based upon the fact are nowadays available. Aims: To evaluate a cosmetic hyaluronan lotion (Dr. Fukaya’s skin repair lotion or Hyaluprotect) from the viewpoint of anti-aging effects and to consider its mechanism. Patients/Methods: I...

The polysaccharide hyaluronan (HA) (synonyms - hyaluronic acid, hyaluronate) is a versatile, polymorphic, glycosoaminoglycan with vast biological functions. HA is found throughout the body, primarily residing in skin, thus playing an important role in wound healing. Research regarding HA's function has changed over the years, primarily focussing on a particular aspect or function. The contribut...

bovine oocytes matured in culture were denuded from cumulus cells with hyaluronidase and by repeat pipetting trough a fine pasture pipete and were inseminated with frozen-thawed spermatozoa in a protein-free bo medium containing 5m m-caffeine, l0 mg heparin/ml and with or without polyvinyl pyrrolidone (pvp) and different concentrations of hyaluronic acid. when oocytes were inseminated in the ab...

Hyaluronan (hyaluronic acid) is a simple, nonantigenic, nonsulfated glycosaminoglycan present everywhere in the extracellular compartments of the body. Noteworthy, it is highly conserved phylogenetically, from sauropsida to mammals; and plays a plethora of roles from embryonic/fetal development to adult physiological and pathological events, including tumor development. In reproduction, hyaluro...