A new specific, precise, accurate, and robust TLC-densitometry has been developed for the simultaneous determination of hydrocortisone acetate and lidocaine hydrochloride in combined pharmaceutical formulation. The chromatographic analysis was carried out using a mobile phase consisting of chloroform+acetone+ammonia (25%) in volume composition 8:2:0.1 and silica gel 60F254 plates. Densitometric...

One of the most difficult problems in the study of rheumatic diseases is the evaluation of an antiinflammatory response. That this is true in intraarticular as well as systemic therapy is illustrated by the divergence of results reported in the literature. For example, Cohen and others (1954) concluded, by purely clinical evaluation in a large number of patients, that cortisone acetate was equa...

BACKGROUND The efficacy of topical ophthalmic corticosteroids depends upon small modifications in preparations, such as drug concentration.The aim of this study was to confirm that hydrocortisone acetate (HC-ac) ophthalmic ointments of 2.5% and 1% are more effective than a 0.5% eye ointment. METHODS In this randomized, double-blind, placebo-controlled, parallel-group clinical study, the chang...

The use of intra-articular steroids in the treatment of osteo-arthritis of the knee joints has not been much discussed in the literature. Burgess (1957) states that intra-articular hydrocortone is of most value in joints distended by synovial fluid. Williams (1958) found that hydrocortisone tertiarybutylacetate was effective over a longer period than hydrocortisone, but that both might dramatic...

For decades, compounding dermatologists have employed sulfur with topical hydrocortisone acetate for chronic facial conditions like rosacea and seborrheic dermatitis. The addition of precipitated sulfur prevented the development of acneiform eruptions, rebound phenomenon, and perioral dermatitis from the hydrocortisone. Even after long term use, these compounds can be discontinued without rebou...

The changes of magnesium utilization during pregnancy in rat and the influence of hydrocortisone acetate on it was studied. In the late days of gestation the Mg balance and magnesium content of bone increased significantly. This may be due to a greater requirement at this stage and to bone acting as a store for this cation. Hydrocortisone acetate at a dose of 4 mg/100 g body weight/day decrease...

1. In mice rendered lymphocytopenic by X-irradiation or hydrocortisone acetate, pertussis vaccine evoked both lymphocytosis and polymorphonuclear leukocytosis. 2. When mice with lymphocytosis induced by pertussis vaccine were X-irradiated, prompt and extensive destruction of circulating as well as tissue small lymphocytes occurred. The devitalized circulating cells were cleared from the blood p...