In bone disorders infections are common. The concentration of majority of antibiotics is very low in the bone tissue. A high local dose can be obtained from the ciprofloxacin-loaded hydroxyapatite nanoparticles. The present study is aimed at developing the use of hydroxyapatite and zinc-doped hydroxyapatite nanoparticles as a carrier for ciprofloxacin drug delivery system. The ciprofloxacin-loa...

BACKGROUND Ceramic hydroxyapatites and non-ceramic hydroxyapatites have been used extensively as alloplastic materials for bone reconstruction. However, different forms of hydroxyapatite induce different types of tissue response. METHODS Human gingival fibroblasts (FMM1 cells) were used to analyze ceramic and non-ceramic hydroxyapatite biocompatibility. The cells were grown on surfaces covere...

Hydroxyapatite (Ca10(PO4)6(OH)2) is one of the implants materials with medical applications due to its higher biocompatibility. The hydroxyapatite found complete utilization after proper preparation of composite. The influence of zirconia (ZrO2) on the phase composition and on mechanical properties of hydroxyapatite-zirconia composites has been previous investigated and reported. Hierarchical c...

Adsorption of Streptococcus mutans on hydroxyapatite and chemically treated hydroxyapatite was studied. Zeta potentials of the surfaces were measured. Chemically treated hydroxyapatite gave higher zeta potentials and lower S mutans adsorption.

A method of synovial fluid preparation giving optimal hydroxyapatite detection as well as definitions of the threshold masses of hydroxyapatite in viscous synovial fluid detectable by x ray diffraction and scanning electron microscopy with energy dispersive analysis is reported. Use of an equal volume of 100% hydrazine with the synovial fluid optimised detection of hydroxyapatite. By x ray diff...

in this study, hydroxyapatite (ha) nanocrystals have been synthesized via chemical precipitation technique. diammonium hydrogen phosphate and calcium nitrate 4-hydrate were used as starting materials and sodium hydroxide solution was used as the agent for ph adjustment. the powder sample was evaluated by techniques such as scanning electron microscope, transmission electron microscope, fourier ...

Hydroxyapatite is chemically related to the inorganic component of bone matrix as a complex structure with the formula of Ca10(OH)2(PO4)6. Previous studies have reported the application of microsized hydroxyapatite to bone regeneration, but the result is not satisfied. The limitation comes from the size of hydroxyapatite. In addition, the duration of treatment is very long. The advantages of hy...

BACKGROUND Nanomaterials have unique advantages in controlling stem cell function due to their biomimetic characteristics and special biological and mechanical properties. Controlling adhesion and differentiation of stem cells is critical for tissue regeneration. METHODS This in vitro study investigated the effects of nano-hydroxyapatite, nano-hydroxyapatite-polylactide- co-glycolide (PLGA) c...

This paper reports a high-yield process to fabricate biomimetic hydroxyapatite nano-particles or nano-plates. Hydroxyapatite is obtained by simultaneous dripping of calcium chloride (CaCl2) and ammonium hydrogen phosphate (NH4)2HPO4 solutions into a reaction vessel. Reactions were carried out under various pH and temperature conditions. The morphology and phase composition of the precipitates w...

For many years, glass-polyalkenoate cements have been described as possessing the unique properties of self-adherence to human hard tissues, such as bones or teeth. However, direct experimental evidence to prove the existence of chemical bonding has not been advanced. X-ray Photoelectron Spectroscopy (XPS) was used to analyze the chemical interaction of a synthesized polyalkenoic acid with enam...