نتایج جستجو برای: hynic toc

تعداد نتایج: 3252  

2016
L. K. Anzola-Fuentes M. Chianelli F. Galli A. W. J. M. Glaudemans L. Martin Martin V. Todino A. Migliore A. Signore

BACKGROUND Human T lymphocytes infiltrating tissues in autoimmune diseases are known to express somatostatin receptors amongst other activation markers. In this study, we evaluated whether somatostatin receptor scintigraphy (SRS) using a radiolabelled somatostatin analogue ((99m)Tc-EDDA/tricine-HYNIC-tyr(3)-octreotide ((99m)Tc-EDDA/HYNIC-TOC)) is able to detect the presence of immune-mediated p...

Journal: :European review for medical and pharmacological sciences 2008
A Migliore A Signore A Capuano E Bizzi U Massafra E Vacca V Todino M Chianelli

We report the case of a 59 years old woman affected by lung and joint sarcoidosis, secondary Sjogren's syndrome refractory to common disease-modifying antirheumatic drugs (DMARDs) that regressed with infliximab and methotrexate. 99mTc-HYNIC-TOC scintigraphy was useful in diagnosis, choice of treatment and follow-up.

Journal: :Revista espanola de medicina nuclear e imagen molecular 2012
J A Mendoza Narváez M E Bellón Guardia A M García Vicente A Palomar Muñoz M P Talavera Rubio A M Soriano Castrejón

A 62-year-old woman diagnosed with a pancreatic neuroendocrine tumor (NET) underwent surgery in 2004 and was reoperated in 2009 for recurrence in the greater curvature of the stomach. Theposterior clinical and radiological controlswerenegative until 2011. InMarch 2011 a somatostatin receptor scintigraphy with 99mTcEDDA/HYNIC-TOC was performed to rule out new recurrence which was suspected due t...

2012
Rong Zhao Jiang Wang Jinglan Deng Weidong Yang Jing Wang

The aim of this study was to investigate the predictive role of the orbital somatostatin receptor scintigraphy with 99mTc-EDDA/HYNIC-TOC (99mTc-TOC) to detect clinical stage of Graves’ ophthalmopathy and the response to corticosteroid therapy. The subjects of the experiment were 46 patients with Graves’ ophthalmopathy (GO) and four volunteers without eye disease or GO as the normal group (NG). ...

2012
Sonja Kuzmanovska Olivija Vaskova Marina Zdraveska Kocovska

The use of radiolabeled peptide ligands as diagnostics and therapeutics in nuclear oncology has increased recently. One of the most frequently used radiopharmaceutical is 99mTc-EDDA/HYNIC-TOC, a somatostatin analog with affinity for certain types of somatostatin receptors, overexpressed in tumors of neuroendocrine origin. The radiopharmaceutical is not readily available; therefore we introduced...

Mohammad Hossein Babaei Mostafa Gandomkar Reza Najafi Seyed Esmail Sadatebrahimi

The high expression of somatostatin receptors in many tumours, have made receptor scintigraphy with 111In-DTPA-Octreotide a widly used procedure in nuclear medicine. Despite its clinical success, some limitation and drawbacks of radiolabelling with 111In remain, especially those concerned with the cost, availability and physical decay properties of this radionuclide. 99mTc-EDDA/HYNIC-Tyr3...

Journal: :iranian journal of nuclear medicine 2004
mostafa gandomkar reza najafi seyed esmail sadatebrahimi mohammad hossein babaei

the high expression of somatostatin receptors in many tumours, have made receptor scintigraphy with 111in-dtpa-octreotide a widly used procedure in nuclear medicine. despite its clinical success, some limitation and drawbacks of radiolabelling with 111in remain, especially those concerned with the cost, availability and physical decay properties of this radionuclide. 99mtc-edda/hynic-tyr3-toc w...

Journal: :Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2003
Michael Gabriel Clemens Decristoforo Eveline Donnemiller Hanno Ulmer Christine Watfah Rychlinski Stephen J Mather Roy Moncayo

UNLABELLED The aim of this study was to compare the imaging abilities of the recently developed somatostatin analog, (99m)Tc-hydrazinonicotinyl-Tyr(3)-octreotide ((99m)Tc-HYNIC-TOC [(99m)Tc-TOC]), with (111)In-diethylenediaminepentaacetic acid-D-Phe(1)-octreotide ((111)In-OCT [Octreoscan]) in patients undergoing routine somatostatin receptor (SSTR) scintigraphy. METHODS Forty-one patients (20...

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