Extracts of Hypericum, Passiflora and Valeriana are used for the treatment of mild depression and anxiety. We were interested whether a combination of Hypericum and Passiflora exerts comparable effects to Hypericum alone. We used two well-established models for investigating extracts for their anti-depressant activity, namely the effects on synaptic uptake of serotonin and the forced-swimming-t...

Hyperatomarin, annulatophenone and gentisein are constituents of Hypericum annulatum Moris – a perennial herb, indigenous to the Balkan Peninsula and Sardinia. The aim of the study was to investigate the effects of these compounds at serotonin binding and uptake in rat brain sinaptosomes. Radioligand techniques with [H]-5HT were used in order to determine a profile of pharmacological activity i...

The flower of Hypericum calycinum, which appears uniformly yellow to humans, bears a UV pattern, presumably visible to insects. Two categories of pigments, flavonoids and dearomatized isoprenylated phloroglucinols (DIPs), are responsible for the UV demarcations of this flower. Flavonoids had been shown previously to function as floral UV pigments, but DIPs had not been demonstrated to serve in ...

Observations: Hypericin, originating from Hypericum perforatum, is a potent photosensitizer known to induce skin phototoxicity when given systemically. Hypericum perforatum is a botanical extracts with anti-inflammatory and antibacterial effect. Photocontact dermatitis is a common cutaneous reaction by various herbs. We describe a 54-year-old female patient with Hypericum perforatum associated ...

OBJECTIVES To compare the efficacy and tolerability of Hypericum perforatum (St John's wort extract) with imipramine in patients with mild to moderate depression. DESIGN Randomised, multicentre, double blind, parallel group trial. SETTING 40 outpatient clinics in Germany. PARTICIPANTS 324 outpatients with mild to moderate depression. INTERVENTION 75 mg imipramine twice daily or 250 mg h...

introduction: previous studies have suggested that plants avena sativa, hypericum perforatum, passiflora incarnata and lavandula officinalis can affect nervous system and reduce neural excitability and pain. the aim of this study was to evaluate the effect of a mixture of these four plant’s alcoholic extract on morphine withdrawal symptoms. methods: experiments were performed on four animal gro...

Skin aging is a process influenced by several factors, including estrogen. Estrogen modulates the physiology of skin, and its deficiency in postmenopausal women accelerates skin aging. Administration estrogen can delay process. Phytoestrogens are estrogen-like compounds derived from plants that administered via oral as well astopical routes. Trigonella foenum-graecum, commonly known fenugreek, ...

BACKGROUND Extracts of Hypericum perforatum (St. John's wort) have been traditionally recommended for a wide range of medical conditions, in particular mild-to-moderate depression. The present study was designed to investigate the effect of Hypericum perforatum treatment in a mouse model of anxiety/depressive-like behavior, induced by chronic corticosterone administration. METHODS CD1 mice we...

Depression is a common condition in the community with a significant impact on affected individuals, their relatives and society. Many patients with depression do not seek treatment and are often concerned about the possible adverse effects of antidepressant drugs. Extract of Hypericum perforatum (St. John's wort) has long been recognized as a treatment for depression. Several published trials ...