Hypertrophic scars and keloids are fibroproliferative disorders that may arise after any deep cutaneous injury caused by trauma, burns, surgery, etc. Hypertrophic scars and keloids are cosmetically problematic, and in combination with functional problems such as contractures and subjective symptoms including pruritus, these significantly affect patients' quality of life. There have been many st...

Although therapeutic management of hypertrophic scars and keloids using contact or spray cryosurgery has yielded significant improvement or complete regression of hypertrophic scars and keloids, it requires one to 20 treatment sessions. This study was designed to assess the clinical safety and efficacy of an intralesional needle cryoprobe method in the treatment of hypertrophic scars and keloid...

BACKGROUND CO2 laser surgery is a treatment modality for cutaneous neurofibromas. OBJECTIVE Hypertrophic and atrophic scars can result from treatment with CO2 laser surgery. We present a case of cutaneous neurofibromatosis that developed hypertrophic scars postoperatively. METHODS Continuous wave CO2 laser surgery therapy was applied to the patient. RESULTS Hypertrophic scars developed 2 ...

Keloids and hypertrophic scars are different expressions of the same derailment of wound healing; their biological behaviors and appearances are quite different. The clinical differences between hypertrophic scars and keloids have long been recognized. However, distinguishing between the two types of scars on histology is sometimes difficult as the ‘keloid collagen’, the hallmark of keloid, is ...

Hypertrophic scars occur following cutaneous wounding and result in severe functional and esthetic defects. The pathophysiology of this process remains unknown. Here, we demonstrate for the first time that mechanical stress applied to a healing wound is sufficient to produce hypertrophic scars in mice. The resulting scars are histopathologically identical to human hypertrophic scars and persist...

Scar formation is a consequence of the wound healing process that occurs when body tissues are damaged by a physical injury. Hypertrophic scars and keloids are pathological scars resulting from abnormal responses to trauma and can be itchy and painful, causing serious functional and cosmetic disability. The current review will focus on the definition of hypertrophic scars, distinguishing them f...

Currently accepted conservative treatments of hypertrophic scars are limited to steroid injections, radiation therapy, and silicone occlusive therapy. However, the use of Mederma for these problematic lesions has become quite prevalent in the clinical setting. Little scientific evidence exists to support the efficacy of this product in reducing hypertrophic scars. The aim of this study was to s...

Aim: The aim of the study was the evaluation in vivo of the differences between the microcirculatory characteristics of the scars (keloids and hypertrophic scars) and healthy skin. Material and methods: Twenty three patients with keloids and twenty with hypertrophic scars were included in the study, evaluating fifty six scar areas and twenty healthy skin areas by means of contact optical probe ...

BACKGROUND A single-center study assessing the efficacy of Nagor's Silgel STC-SE silicone gel to reduce the appearance of hypertrophic and keloid scars. METHODS A 16-week controlled study of 36 patients with hypertrophic or keloid scars. The subjects were divided between 2 cohorts: one assessing recently healed scars (<6 mo) and other assessing older scars (6 mo to 2 y). The efficacy of Silge...