We recruited a group of 6713 consecutive Chinese patients with T2D but normal renal and liver function who were admitted to one of 81 top tertiary care hospitals in China. Mild hypoglycaemia was defined as having symptomatic hypoglycaemia in one month before hospitalization. Severe hypoglycaemia was defined as having hypoglycaemia that needed assistance from other people in three months before ...

a 7-year-old castrated male german shepherd dog was presented with a 10-day history of intermittent lethargy, weakness and episodic seizures. laboratory findings after admission revealed hypoglycaemia and hyperinsulinaemia. provisional diagnosis of insulinoma was made based on the presence of concurrent hypoglycaemia and elevated insulin level. in exploratory laparotomy a small nodular mass was...

The primary cause of hypoglycaemia in Type 2 diabetes is diabetes medication-in particular, those which raise insulin levels independently of blood glucose, such as sulphonylureas (SUs) and exogenous insulin. The risk of hypoglycaemia is increased in older patients, those with longer diabetes duration, lesser insulin reserve and perhaps in the drive for strict glycaemic control. Differing defin...

INTRODUCTION We assessed if patients with known hypoglycaemia present on other occasions with non-specific symptoms associated with (but not diagnosed as) hypoglycaemia, potentially representing missed hypoglycaemia. METHODS 335 primary care records (5/2/12-4/2/13) from patients aged >65 (79 on insulin, 85 on sulphonylureas, 121 on metformin only, 50 without diabetes) were assessed for hypogl...

AIMS To re-analyse, using a series of alternative hypoglycaemia definitions, the data from 2 trials, DUAL I and V, in which the once-daily, fixed ratio combination of insulin degludec/liraglutide (IDegLira) was compared with basal insulin therapy. MATERIAL AND METHODS Post hoc analyses of the DUAL I (patients uncontrolled on oral antidiabetic drugs) and DUAL V (patients uncontrolled on insuli...

Iatrogenic hypoglycaemia is a well-known complication of insulin therapy in patients with diabetes mellitus and a limiting factor for glycaemic control. In a setting of endogenous insulin deficiency (type 1 and advanced type 2 diabetes), one episode of hypoglycaemia reduces both counterregulatory hormone responses to and subjective awareness of subsequent hypoglycaemia, thus impairing physiolog...

Fear of hypoglycaemia is a powerful emotion among patients treated with insulin, and hypoglycaemia remains the major factor limiting attempts to achieve and sustain normoglycaemia with intensive insulin therapy. The Diabetes Control and Complications Trial (DCCT) reported a threefold greater risk of severe hypoglycaemia in those randomised to intensive insulin therapy1,2, with most of the episo...

A 7-year-old castrated male German shepherd dog was presented with a 10-day history of intermittent lethargy, weakness and episodic seizures. Laboratory findings after admission revealed hypoglycaemia and hyperinsulinaemia. Provisional diagnosis of insulinoma was made based on the presence of concurrent hypoglycaemia and elevated insulin level. In exploratory laparotomy a small nodular mass was...

Hypoglycaemia occurring in association with certain extrapancreatic tumours, mesodermal in type and mostly malignant, has become a well-established entity of organic hypoglycaemia. Conn and Seltzer (1955), in a review of spontaneous hypoglycaemia, added this group to the well-known causes of organic hypoglycaemia, namely, pancreatic, hepatic, anterior pituitary, adrenocortical and central nervo...

Several factors can influence the ability to drive by patients with diabetes mellitus. The most important factor would be hypoglycaemia. It seems logical that hypoglycaemia unawareness would be an important risk factor for accidents. However, in everyday practice, hypoglycaemia-related accidents are rare. Moreover, it seems that only a small subset of people with diabetes is responsible for the...