In this study, a new series of quinoxalinone derivatives (5a–5p, 6a–6n) was designed and its hypoglycemic activity evaluated. The results showed that compounds 5i 6b exhibited stronger effects than the lead were comparable to positive control Pioglitazone. may exert by alleviating cellular OS modulating interactions among GLUT4, SGLT2, GLUT1 proteins. compound better 5i, found bind for most scr...

Different doses of ethanolic extract of Stephania glabra tuber were evaluated for antihyperglycemic activity in alloxan induced diabetic mice. The oral administration of 100, 200 and 500 mg/kg body weight showed significant hypoglycemic activity. Glibenclamide (oral hypoglycemic agent, 25 mg/kg, p.o.) has been used as standard.

Background: The mechanism of hypoglycemic and hypolipidemic activities of Pyrus biossieriana Buhse leaf extract (PbBLE) and its phytochemical component arbutin, have not been well determined. The present study was performed to understand the hypoglycemic activity mechanisms of pbBLE and arbutin more clearly.Methods: In vitro enzymatic carbohydrate digestion with PbBLE and arbutin was assessed u...

The objective of the study is to evaluate the hypoglycemic activity of Barringtonia acutangula (BA) fruit extracts i.e. aqueous, methanol and chloroform in streptozotocin (STZ) 50mg /kg induced hyperglycemic Wistar rats. In addition, the effect off all the three extracts of BA fruit on oral glucose tolerance in glucose loaded normal rats was also determined. Aqueous extract (400 mg/kg) treatmen...

Purpose. The present study was designed to investigate the antinociceptive, anxiolytic, CNS depressant, and hypoglycemic effects of the naproxen metal complexes. Methods. The antinociceptive activity was evaluated by acetic acid-induced writhing method and radiant heat tail-flick method while anxiolytic activity was evaluated by elevated plus maze model. The CNS depressant activity of naproxen ...

Phyllanthus amarus is an indigenous medicinal plant, with a folk reputation as hypoglycemic agent in Central and Southern India. In the present investigation hypoglycemic activity of ethanolic leaf extract of Phyllanthus amarus was evaluated using alloxan induced hyperglycemic mice. Blood glucose levels of all the mice of each group were tested before the treatments on fasting mice and then tes...