Hypomagnesaemia and associated hypocalcaemia and hypoparathyroidism have been increasingly recognised as rare long-term side-effects of proton pump inhibitors (PPIs). The PPIs may inhibit active magnesium (Mg) absorption by interfering with transcellular transient receptor potential melastatin-6 and -7 (TRPM 6 and 7) channels. More recent cell culture studies have suggested concomitant inhibiti...

OBJECTIVE Case reports showing that proton-pump inhibitors (PPIs), omeprazole and esomeprazole, can cause hypomagnesaemia have been accumulating since 2006. In this study, the reports submitted to the Adverse Event Reporting System (AERS) of the US Food and Drug Administration (FDA) were evaluated to assess omeprazole and esomeprazole in terms of susceptibility to hypomagnesaemia. METHODS Aft...

Magnesium plays a role in calcium metabolism and hypomagnesaemia can lead to hypocalcaemia.1 Recently it has been recognised that prolonged aminoglycoside therapy can cause hypomagnesaemia.2 3 We have recently observed tetany associated with low serum levels of both calcium and magnesium in a patient receiving gentamicin, which resolved when the gentamicin was stopped and the serum magnesium wa...

Cockburn, F., Brown, J. K., Belton, N. R., and Forfar, J. 0. (1973). Archives of Disease in Childhood, 48, 99. Neonatal convulsions associated with primary disturbance of calcium, phosphorus, and magnesium metabolism. The biochemical relations in 75 newborn infants suffering from convulsions considered to be due to a primary disturbance of mineral metabolism have been studied. Hypocalcaemia was...

BACKGROUND Some observations suggested that magnesium supplementation could be helpful in the treatment of diabetic patients by improving glycemic control and preventing the development of diabetes-related complications. OBJECTIVES To estimate the prevalence of hypomagnesaemia among obese patients with type 2 diabetes attending the National Center for Diabetes, Endocrinology and Genetics (NCD...

Nine patients with acute leukaemia developed a complex syndrome of hypocalcaemia and hypomagnesaemia during treatment. These metabolic abnormalities developed rapidly in some patients and gave rise to acute symptoms. Immunoreactive parathormone concentrations in these patients were found to be either absolutely or inappropriately low. Hypomagnesaemia and the action of chemotherapeutic agents, e...

OBJECTIVES To describe the incidence of renal dysfunction, hypokalaemia and hypomagnesaemia in AIDS patients with cryptococcal meningitis and on amphotericin B treatment. Secondary objective was to determine all-cause mortality in the same group. DESIGN Prospective, observational study. SETTING Kenyatta National Hospital (KNH), Nairobi, Kenya. SUBJECTS Seventy consecutive patients with AI...

Proton pump inhibitor (PPI)-induced hypomagnesaemia is a rare but serious adverse effect of a widely prescribed medication. It has become an increasingly recognised complication since 2006, with the U.S. Food and Drug Administration issuing a warning for this risk with regards to long-term PPI use. We present the case of PPI-associated hypomagnesaemia and hypocalcaemia. A 91 year old male prese...

Hypomagnesaemia is a well known association of diabetes mellitus; it is often asymptomatic but may manifest as tremor, tetany, delirium, hallucinations, or, when severe, generalised seizures. In such instances it is usually associated with hypocalcaemia. We report on a diabetic patient with severe hypomagnesaemia but normocalcaemia who developed focal seizures that proved refractory to conventi...