BACKGROUND Ferric carboxymaltose (FCM) and iron isomaltoside 1000 (IIM) are increasingly used because they allow correction of severe iron deficiency in a single infusion. A transient decrease in serum phosphate concentrations is a frequent side effect of FCM. AIM To characterize this adverse event and search for its predictors in a gastroenterology clinic patient cohort. METHODS Electronic...

We report the first patient with pathologically proven leukoencephalopathy associated with hypophosphatemia. A 61-year-old woman had repetitive episodes of decreased consciousness with pontine and pallidal lesions and extensive leukoencephalopathy on MRI, later found to be associated with hypophosphatemia. Although hypophosphatemia has been linked to central pontine and extrapontine myelinolysi...

Hypophosphatemia has long been reported to be associated with sepsis and has been correlated with sepsis severity. This retrospective study was undertaken at a university hospital to determine whether severe hypophosphatemia could serve as a mortality predictor in septic patients. Charts of 6,190 septic patients who were hospitalized during one year (2001-02) were examined. Fifty-five patients ...

Hypophosphatemia is defined as a serum phosphate level of less than 2.5 mg/dL (0.8 mmol/L). Hypophosphatemia is caused by inadequate intake, decreased intestinal absorption, excessive urinary excretion, or a shift of phosphate from the extracellular to the intracellular compartments. Renal phosphate wasting can result from genetic or acquired renal disorders. Acquired renal phosphate wasting sy...

BACKgRoUnD AnD oBJECTIVES: The aim of this study was to identify the incidence of hypophosphatemia in severe traumatic brain injury (TBI), as well as to investigate the causes and its clinical significance. METHoDS: Fifty-nine serum phosphate determination were done in 14 severe TBI in adults RESUlTS: Seven patients developed hypophosphatemia (< 2 mg/dL). Univariate analysis exhibited associati...

We retrospectively reviewed the charts of 308 admissions to a pulmonary disease ward and 100 admissions to the general medical service over one year to find the prevalence, sequelae, and etiology of hypophosphatemia. The overall prevalence of low serum phosphate levels (less than 2.4 mg/dl) occurring at least once during hospitalization in chest patients was 17 percent, but was higher in patien...

To the Editors: The neuroleptic malignant syndrome (NMS) is a rare but potentially fatal adverse event associated with the use of conventional and atypical antipsychotic medications. In addition to the commonly observed symptoms of fever, muscular rigidity, autonomic dysregulation, and delirium, several abnormalities in laboratory indices are also associated with NMS. Laboratory abnormalities c...

Hypophosphatemia occurs in 40 to 60% of patients with acute malaria, and in many other conditions associated with elevations of body temperature. To determine the prevalence and causes of hypophosphatemia in patients with malaria, we retrospectively studied all adults diagnosed with acute malaria during a 12-year period. To validate our findings, we analyzed a second sample of malaria patients ...