This study analyzed the role of nitric oxide (NO) and endothelium-derived hyperpolarizing factor (EDHF) in the abnormal renal vascular reactivity of hypothyroid rats. Renal responses to vasoconstrictors [VC: phenylephrine (PHE) and ANG II] and vasodilators [VD: ACh, sodium nitroprusside (SNP), and papaverine (PV)] were studied in kidneys from control and hypothyroid rats under normal conditions...

To better characterize the increase in lipoprotein lipase (LPL) translation by hypothyroidism, adipocytes were prepared from control and hypothyroid rats. Whereas LPL synthesis was higher in hypothyroid adipocytes, with no change in mRNA levels, there was no increase in hormone-sensitive lipase (HSL) synthesis. To determine whether a transacting translation regulatory factor was present, a cyto...

backgrounds: thyroid hormones play an important physiological role in human metabolism. erythrocyte abnormalities are frequently associated with thyroid disorder. however, they are rarely investigated and related to the subclinical and primary hypothyroidism in kashmiri patients. in this study an attempt was made to study hematological parameters in untreated and treated subclinical hypothyroid...

Background: A fundamental duty of the immune system is to defend against infectious agents. Significant abnormalities were reported in immune parameters of hypothyroid and hyperthyroid patients. In this study, we aim to assess various quantities of antibodies against the tetanus toxin (anti-TT) in hypothyroid and hyperthyroid patients.  Materials and Methods: Anti-TT levels were measured in se...

BACKGROUND Thyroid function disorders lead to changes in the lipoprotein metabolism. OBJECTIVES To study the lipid and the glycaemic abnormalities in the subclinical hypothyroidism cases and to compare the same with the euthyroid, overt hypothyroid and the hyperthyroid subjects. METHODOLOGY Four groups, euthyroid (Group-I), hypothyroid (Group-II), subclinical hypothyroid (Group-III) and hyp...

Lipoprotein profiles in experimental hypercholesterolemia were studied using euthyroid and hypothyroid cholesterol-fed rats. In both groups, serum cholesterol concentration increased, but to a lesser extent in the cholesterol-fed euthyroid rats, with similar changes in distribution among lipoprotein fractions in both groups. Agarose electrophoresis of plasma and individual lipoprotein fractions...

The change in responsiveness to alpha-adrenergic stimulation and to calcium ions in amylase release from parotid glands of hypothyroid rats was compared with that in euthyroid rats. Calcium depletion and addition of verapamil or W-7 in the medium caused a decrease in methoxamine-induced amylase release in both eu- and hypothyroid rats. Moreover, addition of calcium ions to Ca2+-free medium mark...

histochemical changes in the hippocampus of hypothyroid rat at the postpubertal stage, and the possible ameliorating effect of folic acid. Fifty male albino rats were equally divided into five groups; first and second groups were the control and folic acid groups respectively while third group was the hypothyroid group in which rats received PTU in drinking water for six weeks. The fourth and f...

Thyroid status is an important determinant of cardiovascular function. We studied the changes in the aorta of hypothyroid rat at the post-pubertal stage, in addition to the ameliorating role of folic acid. Fifty male albino rats were equally divided into five groups; the first and second groups were the control and folic acid groups, respectively while the third group was the hypothyroid group ...

Thyroid hormones play an important role in cardiac electrophysiology through both genomic and nongenomic mechanisms of action. The effects of triiodothyronine (T(3)) on the electrophysiological properties of ventricular myocytes isolated from euthyroid and hypothyroid rats were studied using whole cell patch clamp techniques. Hypothyroid ventricular myocytes showed significantly prolonged actio...