A new statistical signal processing method, which was called independent component analysis (ICA) was used to extract sub-signals of heart rate variability (HRV). Ten healthy volunteers (4F, 6M) were involved in this study. Electrocardiogram (ECG) recording was consisted of 6min when the volunteer was lying and another 6min when the volunteer was standing. HRV was extracted from ECG. According ...

The murine Wand Steelloci encode the Kit receptor tyrosine kinase and its ligand, Steel factor, respectively. Loss of function mutations at either the Wor SI loci lead to a variety of pleiotropic developmental defects, including mast cell deficiency and severe macrocytic anemia. In addition to these loss-of-function mutations, gain-of-function mutations in ckit, leading to constitutive activati...

We report a three generation family with Beckwith Wiedemann syndrome (BWS) in whom we have identified a 330 kb deletion within the KCNQ1 locus, encompassing the 11p15.5 Imprinting Centre II (IC2). The deletion arose on the paternal chromosome in the first generation and was only associated with BWS when transmitted maternally to subsequent generations. The deletion on the maternal chromosome wa...

The aim of this study was to evaluate immunocastration (vaccination against GnRH using Improvac® vaccine), as an alternative to surgical castration in heavy male pigs (average live weight 165 ± 10 kg), used in the production of Italian typical dry-cured ham. A total of 60 Landrace × Large White male pigs were assigned to three groups of 20 units, including one group of surgically castrated (SC)...

In an endeavor to further characterize human intercellular adhesion molecule-2 (ICAM-2), two murine monoclonal antibodies (mAb) were generated to ICAM-2 transfected COS cells, and designated CBR-IC2/1 and CBR-IC2/2. Immunoprecipitated, reduced ICAM-2 migrated as a broad band of Mr 60,000 in sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Treatment with N-glycanase revealed a peptide ...

Piyu Yue, a research associate at the IC2 Institute, University of Texas at Austin, was a visiting scholar at the Federal Reserve Bankof St. Louis when this article was written. Lynn Dietrich providedresearch assistance. The author would like to thank A. Charnes, Roll Fare and Shawna Grosskopf for theirconstructive comments and useful suggestions. Their DEA computer code led to a significant im...

OBJECTIVE To evaluate safety (primary objective) and efficacy of increasing doses (400 U up to 800 U) of incobotulinumtoxinA (Xeomin, Merz Pharmaceuticals GmbH) for patients with limb spasticity. METHODS In this prospective, single-arm, dose-titration study (NCT01603459), patients (18-80 years) with spasticity due to cerebral causes, who were clinically deemed to require total doses of 800 U ...

Whey edible films (EFs) functionalized with essential oils have a high potential to be used on various foods due their antimicrobial and antioxidant activities. Encapsulation is applied for better retention of volatiles in EFs; however, the functional properties EFs are modified. The containing thyme oil (TEO) encapsulated by co-precipitation β-CD, developed three formulae, inclusion complexes ...

Nicotinamidase (Nic) is a key zinc-dependent enzyme in NAD metabolism that catalyzes the hydrolysis of nicotinamide to give nicotinic acid. A multi-scale computational approach has been used to investigate the catalytic mechanism, substrate binding and roles of active site residues of Nic from Streptococcus pneumoniae (SpNic). In particular, density functional theory (DFT), molecular dynamics (...