Nephrotic syndrome is a common renal disorder in children, characterized by nephrotic range proteinuria, hypoalbuminemia, hyperlipidemia, and edema. The most common type is primary (idiopathic) associated with minimal change disease, which responds very well to steroid therapy and has a good long-term prognosis. Other causes, clinical presentation, laboratory findings, and management are discus...

Pediatric Nephrotic Syndrome is a renal disorder of children, characterized by nephrotic range proteinuria, hypoalbuminemia, hyperlipidemia and edema. The most common type is primary (idiopathic) associated with minimal change disease, which responds very well to steroid therapy and has a good long-term prognosis. Other causes, clinical presentation, laboratory findings and management are discu...

PURPOSE The use of a 12-week steroid regimen (long-term therapy, LT) for the first episode of idiopathic nephrotic syndrome (NS) reportedly induces a more sustained remission and lower relapse rate than previous regimens, including an 8-week steroid regimen (short-term therapy, ST). Here, we assessed the potential for selective application of 2 steroid regimens (LT vs. ST) based on the days to ...

AIM To describe the demographic, clinical features, steroid response, histopathology and complications of all children diagnosed with idiopathic nephrotic syndrome (INS) in New Zealand over a 3-year period. METHODS A questionnaire seeking relevant clinical information was sent to all paediatricians who reported a new case of nephrotic syndrome to the New Zealand Paediatric Surveillance Unit. ...

BACKGROUND The most common cause of idiopathic nephrotic syndrome in children and younger adults is the minimal change nephrotic syndrome (MCNS). In the elderly MCNS is relatively uncommon. Over the last decade some reports suggest a rare but possible association with the administration of various vaccines. CASE PRESENTATION A 82-year old Caucasian female presented with pronounced nephrotic s...

Between 1973 and 1982 there was a significantly higher incidence of minimal change nephrotic syndrome among Asian compared with non-Asian children in Leicestershire. Most Asians in Leicestershire are Gujarati-speaking Hindus, but Sikhs and Muslims are also represented; no group of Asians (defined by religion, language, or birthplace) was at special risk of developing nephrotic syndrome. Nephrot...