UKM CP merupakan salah satu yang bergerak di industri mebel Kota Padang dan memproduksi lemari, meja makan, tempat tidur. Permasalahan terjadi adalah penjualan produk cenderung stagnan menunjukkan tren menurun pada beberapa produk. Penurunan berkisar antara 46-72%. Hal ini disebabkan tidak mengevaluasi strategi pemasaran produknya minim inovasi. Tujuan dari studi untuk meningkatkan dengan mengg...

eIF4E plays a conserved role in initiating protein synthesis, but with multiple eIF4E isoforms present in many organisms, these proteins also adopt specialized functions. Previous RNAi studies showed that ife-3, encoding the sole canonical eIF4E isoform of Caenorhabditis elegans, is essential for viability. Using ife-3 gene mutations, we show here that it is maternal ife-3 function that is esse...

Regulated mRNA translation is vital for germ cells to produce new proteins in the spatial and temporal patterns that drive gamete development. Translational control involves the de-repression of stored mRNAs and their recruitment by eukaryotic initiation factors (eIFs) to ribosomes. C. elegans expresses five eIF4Es (IFE-1-IFE-5); several have been shown to selectively recruit unique pools of mR...

The rate-limiting step for cap-dependent translation initiation in eukaryotes is recruitment of mRNA to the ribosome. An early event in this process is recognition of the m7GTP-containing cap structure at the 5'-end of the mRNA by initiation factor eIF4E. In the nematode Caenorhabditis elegans, mRNAs from 70% of the genes contain a different cap structure, m32,2,7GTP. This cap structure is poor...

considering current situation and approaching one, car-component manufacturers should choose an appropriate strategy so that this strategy can help them survive in competitive market of manufacturing. sahand khodro company as a small car-component manufacturer, is located in industrial town of shahid rajaie in tabriz. comprehensive framework for strategy formulation is used to formulate sahand ...

Abstract. This paper is to develop immersed finite element (IFE) functions for solving second order elliptic boundary value problems with discontinuous coefficients and non-homogeneous jump conditions. These IFE functions can be formed on meshes independent of interface. Numerical examples demonstrate that these IFE functions have the usual approximation capability expected from polynomials emp...

Type XVII collagen (COL17) is a transmembrane protein located at the epidermal basement membrane zone. COL17 deficiency results in premature hair aging phenotypes and in junctional epidermolysis bullosa. Here, we show that COL17 plays a central role in regulating interfollicular epidermis (IFE) proliferation. Loss of COL17 leads to transient IFE hypertrophy in neonatal mice owing to aberrant Wn...

Translation initiation factor eIF4E binds the m(7)G cap of eukaryotic mRNAs and mediates recruitment of mRNA to the ribosome during cap-dependent translation initiation. This event is the rate-limiting step of translation and a major target for translational control. In the nematode Caenorhabditis elegans, about 70% of genes express mRNAs with an unusual cap structure containing m(3)(2,2,7)G, w...

This article presents new immersed finite element (IFE) methods for solving the popular second order elliptic interface problems on structured Cartesian meshes even if the involved interfaces have nontrivial geometries. These IFE methods contain extra stabilization terms introduced only at interface edges for penalizing the discontinuity in IFE functions. With the enhanced stability due to the ...

BACKGROUND The flowers of Inula japonica (Inulae Flos) have long been used in traditional medicine for the treatment of inflammatory diseases. In the present study, we investigated the anti-inflammatory properties of Inulae Flos Extract (IFE). METHODS The anti-inflammatory effects of IFE against nitric oxide (NO), PGE(2), TNF-α, and IL-6 release, as well as NF-κB and MAP kinase activation wer...