antiphospholipid antibodies (apla) may be detected in normal pregnancies and also may cause thrombosis, recurrent fetal loss, placental infarction and preeclampsia. in the present study the possible differences in apla titer between healthy pregnant women and preeclampsia cases without history of thrombosis was examined. the apla titer in 50 healthy pregnant women with 50 preeclampsia cases wit...

http://dx.doi.org/10.1016/j.ymgmr.2014.01.001 2214-4269/© 2014 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND licen (http://creativecommons.org/licenses/by-nc-nd/3.0/). Patients with late-onset Pompe disease receiving enzyme replacement therapy (ERT) usually develop IgG antibodies against algucosidase alpha (anti-rhGAA) within the first 3 months. Th...

To assess the problem of CMV infection in pregnant women in Sohag community and to determine the risk of congenital CMV infection. The study was performed on 900 pregnant women residing in Sohag, during the period from June, 2006 till January 2010. Detection of CMV antibodies (IgM and IgG) was carried out using microparticle enzyme immunoassay. Women proved positive (+ve) for CMV IgM or IgG ant...

Artery Disease To the Editor: Recently, Ridker et al published their observations about cytomegalovirus (CMV) and atherosclerosis.1 They found that “there is no evidence of a positive association between baseline IgG antibodies directed against CMV or HSV [herpes simplex virus] and the development of future MI [myocardial infarction] or thromboembolic stroke. Furthermore, we found no evidence o...

The effect on liver and heart allograft survival (ACI rats to Lewis rats) was studied after three methods of recipient presensitization and after different intervals between sensitization and transplantation. With comparable lymphocytotoxic antibody titers, liver allografts always survived longer than heart grafts. The titer, class and specificity of the antibodies varied with the method of sen...

A sensitive solid-phase radioimmunoassay for detection of antibodies to varicella-zoster virus (VZV) is described. The antigen consisted of a sonically disrupted extract of VZV-infected human embryo cells. 125I-labeled rabbit anti-human immunoglobulin G (IgG) specific for the Fc portion of human IgG was used to detect human IgG bound to viral antigen. With this technique, 193 human sera were ev...

The routine brucella agglutination test measures both immunoglobulin M (IgM) and IgG brucella antibody titers; however, only an elevated IgG titer is significant for differentiating active from inactive disease in patients with symptoms lasting 3 or more weeks. The IgG antibody titer can be determined by treating the serum wih 2-mercaptoethanol to inactivate the IgM brucella antibodies while le...