نتایج جستجو برای: il28b polymorphisms

تعداد نتایج: 67261  

Journal: :jundishapur journal of microbiology 0
fateme zare department of immunology, reproductive immunology research center, shahid sadoughi university of medical sciences, yazd, ir iran hossein hadinedoushan department of immunology, reproductive immunology research center, shahid sadoughi university of medical sciences, yazd, ir iran; department of immunology, reproductive immunology research center, shahid sadoughi university of medical sciences, yazd, ir iran. tel: +98-3536285406, fax: +98-3536238561 mohsen akhondi meybodi depatment of gastrology, faculty of medicine, shahid sadoughi hospital, shahid sadoughi university of medical sciences, yazd, ir iran mahdi dehghanmanshadi department of immunology, reproductive immunology research center, shahid sadoughi university of medical sciences, yazd, ir iran seyyed ali mirghanizade bafghi department of immunology, reproductive immunology research center, shahid sadoughi university of medical sciences, yazd, ir iran mahmood vakili department of community, faculty of medicine, shahid sadoughi university of medical sciences, yazd, ir iran

conclusions our findings indicate that patients with the homozygous cc genotype in the il28b gene had a significantly higher rate of response to treatment than those with the tt or ct genotypes. nor does the il28b rs12979860 polymorphism affect the viral load. results the genotype frequencies of rs12979860 polymorphism in group 1 were cc (28.9%), ct (37.8%) and tt (33.3%) and in group 2 were cc...

2015
Kessarin Thanapirom Sirinporn Suksawatamnuay Wattana Sukeepaisarnjaroen Pisit Tangkijvanich Sombat Treeprasertsuk Panarat Thaimai Rujipat Wasitthankasem Yong Poovorawan Piyawat Komolmit Chen-Hua Liu

Pretreatment serum levels of interferon-γ-inducible protein-10 (IP-10, CXCL10) and dipeptidyl peptidase-4 (DPP IV) predict treatment response in chronic hepatitis C (CHC). The association between functional genetic polymorphisms of CXCL10 and DPP4 and treatment outcome has not previously been studied. This study aimed to determine the association between genetic variations of CXCL10 and DPP4 an...

Journal: :Antiviral therapy 2011
Takeji Umemura Satoru Joshita Suguru Yoneda Yoshihiko Katsuyama Tetsuya Ichijo Akihiro Matsumoto Kaname Yoshizawa Masao Ota Eiji Tanaka

BACKGROUND Both IL28B gene polymorphisms and serum levels of interleukin (IL)-10, IL-12p40 and IL-18 have been reported to affect the outcome of natural and pegylated interferon and ribavirin-treated HCV infection. METHODS To clarify their association and predictive value in treatment outcome of genotype 1 HCV-infected patients, we measured pretreatment serum IL-10, IL-12p40 and IL-18 levels ...

Journal: :Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2013
Wai-Kay Seto Danny Ka-Ho Wong Malgorzata Kopaniszen Petroula Proitsi Pak-Chung Sham Ivan Fan-Ngai Hung James Fung Ching-Lung Lai Man-Fung Yuen

BACKGROUND The roles of single-nucleotide polymorphisms (SNPs) at HLA-DP and IL28B loci on hepatitis B surface antigen (HBsAg) seroclearance in chronic hepatitis B (CHB) infection are unknown. METHODS We compared the HLA-DP (rs3077, rs9277378, rs3128917) and IL28B (rs12979860, rs8099917) polymorphisms of 203 CHB patients achieving spontaneous HBsAg seroclearance with 203 age- and sex-matched ...

2016
Renwen Zhang Cuiping Shao Na Huo Minran Li Xiaoyuan Xu

BACKGROUND/AIMS Several studies have demonstrated that serum interferon-γ-inducible-protein-10 (IP-10) levels at baseline and single nucleotide polymorphisms (SNPs) near the IL28B gene were associated with viral response and treatment outcomes. Our purpose was to assess the combination of pretreatment IP-10 levels with IL28B SNPs as predictors of treatment response to pegylated interferon α-2a ...

Journal: :Balkan medical journal 2015
Serpil Taheri Bilgehan Aygen Keziban Korkmaz Orhan Yıldız Gökmen Zararsız Halit Canatan

BACKGROUND Host genetic factors can affect the progress of hepatitis-C virus (HCV) infection. Interleukin-28B (IL28B) single nucleotide polymorphisms may play an important role in the clearance of HCV spontaneously or with treatment. AIMS The aim of our study was to evaluate the rate of IL28B genotypes in patients with Chronic Hepatitis-C (CHC) and healthy control subjects and to examine the ...

2015
Francesco Bellanti Gianfranco Lauletta Rosanna Villani Maria Rosaria Lipsi Maria Iole Natalicchio Domenico Sansonno Gianluigi Vendemiale Gaetano Serviddio Castiella. Agustin

Chronic hepatitis C is commonly associated with extrahepatic manifestations. Cryoglobulins are observed in 40% to 60% of such patients and their presence seems to modify response to therapy. The new antivirals are greatly improving the sustained virological response (SVR); however, their high cost limits the use, leaving pegylated interferon plus ribavirin (PR) still the standard-of-care therap...

Journal: :Human immunology 2012
Satoru Joshita Takeji Umemura Yoshihiko Katsuyama Yuki Ichikawa Takefumi Kimura Susumu Morita Atsushi Kamijo Michiharu Komatsu Tetsuya Ichijo Akihiro Matsumoto Kaname Yoshizawa Nozomi Kamijo Masao Ota Eiji Tanaka

IL28B single nucleotide polymorphisms (SNPs) are associated with spontaneous and treatment-induced elimination of hepatitis C virus (HCV). To assess whether the IL28B rs8099917 SNP also affects the progression of chronic HCV infection, we genotyped 511 Japanese HCV patients, including 69 with hepatocellular carcinoma (HCC). The T/T genotype of rs8099917 was not associated with the development o...

2012
Francesc Vidal Miguel López-Dupla Montserrat Laguno Sergi Veloso Josep Mallolas Javier Murillas Carmen Cifuentes Lluis Gallart Teresa Auguet Gloria Sampériz Antoni Payeras Pilar Hernandez Mireia Arnedo Josep Ma Gatell Cristóbal Richart

BACKGROUND AND AIMS This was a safety and efficacy pharmacogenetic study of a previously performed randomized trial which compared the effectiveness of treatment of hepatitis C virus infection with pegylated interferon alpha (pegIFNα) 2a vs. 2b, both with ribavirin, for 48 weeks, in HCV-HIV coinfected patients. METHODS The study groups were made of 99 patients (efficacy pharmacogenetic substu...

Journal: :The Journal of infectious diseases 2011
Fuat Kurbanov Mohamed Abdel-Hamid Rachel Latanich Jacquie Astemborski Mostafa Mohamed Nabiel Mh Mikhail Mai El-Daly Sherif El-Kafrawy David L Thomas Chloe L Thio

Single-nucleotide polymorphisms (SNPs) around IL28B are associated with spontaneous hepatitis C virus (HCV) clearance of genotypes 1 and 3 in white and African-American populations. This study investigated whether the IL28B SNP (rs12979860) is associated with spontaneous clearance of HCV, principally genotype 4, in 162 Egyptians (80 with clearance). The protective C allele was more common in th...

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