نتایج جستجو برای: il7r
تعداد نتایج: 206 فیلتر نتایج به سال:
BACKGROUND Pediatric acute lymphoblastic leukemia (ALL) is the most common childhood cancer and the leading cause of cancer-related mortality in children. T cell ALL (T-ALL) represents about 15% of pediatric ALL cases and is considered a high-risk disease. T-ALL is often associated with resistance to treatment, including steroids, which are currently the cornerstone for treating ALL; moreover, ...
Multiple sclerosis (MS) and neuromyelitis optica (NMO), which are referred to as inflammatory demyelinating diseases (IDDs), are autoimmune diseases affecting the central nervous system. Interleukin‑7 receptor (IL7R) encodes for a receptor protein that is important in the development of immune cells. Several studies have reported significant associations between IL7R polymorphisms and MS. The a...
background: multiple sclerosis (ms) is a chronic inflammatory demyelinating and neurodegenerative disease of central nervous system with unknown causes. etiology of ms involves both genetic and environment factors. the interleukin 7 receptor (il7r) gene is a promising candidate for ms, because its involvement in the autoimmunity, regulation of the t-cell homeostasis...
Review on IL7R, with data on DNA/RNA, on the protein encoded and where the gene is implicated.
Multiple sclerosis (MS) is an autoimmune disorder where T cells attack neurons in the central nervous system (CNS) leading to demyelination and neurological deficits. A driver of increased MS risk is the soluble form of the interleukin-7 receptor alpha chain gene (sIL7R) produced by alternative splicing of IL7R exon 6. Here, we identified the RNA helicase DDX39B as a potent activator of this ex...
BACKGROUND Multiple sclerosis (MS) is a chronic inflammatory demyelinating and neurodegenerative disease of central nervous system with unknown causes. Etiology of MS involves both genetic and environment factors. The interleukin 7 receptor (IL7R) gene is a promising candidate for MS, because its involvement in the autoimmunity, regulation of the T-cell homeostasis, proliferation, and anti-apop...
T-cell acute lymphoblastic leukemia is caused by the accumulation of multiple oncogenic lesions, including chromosomal rearrangements and mutations. To determine the frequency and co-occurrence of mutations in T-cell acute lymphoblastic leukemia, we performed targeted re-sequencing of 115 genes across 155 diagnostic samples (44 adult and 111 childhood cases). NOTCH1 and CDKN2A/B were mutated/de...
Foxo transcription factors have a conserved role in the adaptation of cells and organisms to nutrient and growth factor availability. Here we show that Foxo1 has a crucial, nonredundant role in T cells. In naive T cells, Foxo1 controlled the expression of the adhesion molecule L-selectin, the chemokine receptor CCR7 and the transcription factor Klf2, and its deletion was sufficient to alter lym...
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