Using a new technique for antigen localization. we have demonstrated platelet proteins in megakaryocytes in plastic-embedded biopsy specimens of normal human bone marrow. In a series of 25 specimens. megakaryocytes showed labeling with antibodies to the integral membrane glycoproteins lIla. llb. and the lIb-Illa complex; granule membrane protein 140; and five alpha-granule matrix proteins: thro...

Using a new technique for antigen localization. we have demonstrated platelet proteins in megakaryocytes in plastic-embedded biopsy specimens of normal human bone marrow. In a series of 25 specimens. megakaryocytes showed labeling with antibodies to the integral membrane glycoproteins lIla. llb. and the lIb-Illa complex; granule membrane protein 140; and five alpha-granule matrix proteins: thro...

muslim scholars differ widely on the meaning of the pure word ‘lā illāha illa allāh’ (there is no god expect for god) and its indication to monotheism. a number of possibilities have been raised pertaining to this exalted verse and if some of them are accepted as true, the word tawhīd will not signify complete unity and monotheism. after thoroughly examining the meanings claimed for the words e...

We have previously demonstrated the isolation of platelet membrane glycoprotein lIb-Illa by affinity chromatography with a specific monoclonal antibody.1 We have now separated the polypeptide subunits lIb and lIla of the isolated glycoprotein by preparative sodium dodecyl sulfate polyacrylamide gel electrophoresis and have compared their structural features. Both llb and lIla contain -.1 5% car...

Vivamus, mea Lesbia, atque amemus, rumoresque senum severiorum omnes unius aestimemus assis. Soles occidere et redire possunt; nobis, cum semel occidit brevis lux, nox est perpetua una dormienda. Da mi basia mille, deinde centum, dein mille altera, dein secunda centum, deinde usque altera mille, deinde centum, dein, cum milia multa fecerimus, conturbabimus illa, ne sciamus, aut nequis malus inv...

In a previous study, we reported that adult T-cell leukemia (ATL) cells produce interleukin 1 (II I Hike factors that stimulate murine thymocyte proliferation, the production of interleukin 2 (IL2), and the expression of IL2 receptors (IL2R) on normal human T-cells in the presence of concanavalin A. In this communication, we studied the effect of ILI on the growth of ATL cells in vitro. When AT...

Changes in intracellular Ca2 concentrations (ICa2 ]j) in platelets stimulated with aggregating agents were measured with the fluorescent indicator dye quin 2. Ca2 influx, but not intracellular mobilization, in response to adenosine diphosphate (ADP). platelet aggregating factor (PAFacether). and sodium arachidonate was significantly inhibited by monoclonal antibodies against the glycoprotein (G...