In this issue of the JCI, Shushakova et al. (1) describe experimental results that provide a direct link between the C5a anaphylotoxin and the IgG Fc receptors (FcγRs) in mediating immune complex–triggered (IC-triggered) inflammatory disease. Using a murine lung model of IC-induced inflammation, the authors demonstrate that C5a, acting through the C5a receptor (C5aR), exacerbates inflammation i...

Early, after in utero infection with LCM virus, SWR/J and HA/ICR mice developed manifestations of immune complex disease. Observations based on nursing such mice with virus-infected, immune, or noninfected mouse mothers indicated that maternal antiviral antibody was responsible for the early immune complex glomerulonephritis. Despite comparable viral persistance, in utero-infected offspring fai...

Several studies have focused on polymorphisms of major histocompatibility complex (MHC) in sheep, Ovar-MHC. This molecule plays a pivotal role in antigen presentation for eliciting immune responses against invading pathogens. The best-characterized genetic control of disease resistance and immune response in animals is associated with MHC. Numerous molecular genetic investigations have been und...

complex inherited diseases affected by an interaction between collective effects of the genotype at one or multiple loci either to increase or to lower susceptibility to disease, combined with a variety of environmental exposures that may trigger, accelerate, exacerbate, or protect against the disease process. the new aspects of genetic techniques have been opened for diagnosis and analysis of ...

The clinical, histological, and immunohistochemical features of two cases of apparently isolated arteritis of the epididymis are presented. The aetiology and pathogenesis of the condition are discussed. Immunoglobulin and complement were shown in the acute arterial lesions, but this is not conclusive evidence that isolated arteritis is either an immune complex disease or a forme fruste of polya...