Les déficits immunitaires humoraux (DIH) sont des maladies hétérogènes allant des formes asymptomatiques rencontrés lors des déficits sélectifs en immunoglobulines A (IgA) et en sous-classes d'IgG aux formes graves des agammaglobulinémies congénitales.Les patients atteints de DIH présentent souvent des infections ORL ou des voies respiratoires récidivantes ou sévères. Ces patients peuvent prése...

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Point mutation is an important bio-chemical process related to many genetically transmitted diseases. The present work focuses on Ala→ Phe mutation through analysis of the geometric and energetic consequences of such structural changes. Employing Density Functional Theory (DFT), Pro-Ala-Pro (PAP) and Pro-Phe-Pro (PFP) tri-peptide models were geometry optimised at the B3LYP/6-31G(d) level of the...

Le purpura thrombopénique immunologique est une maladie auto-immune rare qui associe destruction périphérique des plaquettes et insuffisance de production médullaire. Sa physiopathologie mieux en comprise : elle implique réponse immunitaire humorale au cours laquelle les lymphocytes B, via coopération lymphocytaire T, notamment avec T folliculaires auxiliaires spléniques, vont se différencier p...

AIM To examine plasma concentration of IgA, IgM, IgG classes, and IgG1, IgG2, IgG3, and IgG4 subclasses in children with autism. METHODS Infantile autism was diagnosed by the Diagnostic and Statistical Manual for Mental Disorders (DSM)-IV and the International Classification of Diseases (ICD)-10 criteria. Plasma samples were collected from 35 autistic subjects, and their 21 siblings (biologic...

Heparin induced thrombocytopenia (HIT) is a severe complication of heparin therapy. It is generally accompanied by a paradoxical decrease in platelets leading to activation of platelets and of the coagulation system. HIT type I is a mild, transient, non-immune disorder. HIT type II is an immune-mediated reaction towards neo-antigen on PF4, which is platelet factor 4 (PF4) that is exposed upon b...