A simple, novel, label-free impedimetric aptasensor with signal amplification is developed for ultrasensitive detection of small molecules on a carbon nanotubes-based sensing platform by combining target-induced release of the aptamers and nuclease cleavage-assisted target recycling.

The cardiotoxicity induced by doxorubicin are often studied by conventional techniques which are expensive and the experiment ends with the death of cells in culture. Thus a new impedance technique is needed to study the cardiotoxicity by overcoming the drawbacks of conventional techniques. The present paper discusses the measurement of cytotoxicity of doxorubicin on cardiomyocytes of neonatal ...

The present paper describes a comparative characterization of cytotoxic effects of doxycycline and cisplatin on osteosarcoma cells by using impedance sensing techniques. The impedance sensing device was obtained from Applied Physics and the osteosarcoma cells were cultured on the electrodes of the purchased devices. The impedimetric cytotoxic natures of both the drugs on cells are investigated ...

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This status report overviews activities of the German gas sensor research community. It highlights recent progress in the field of potentiometric, amperometric, conductometric, impedimetric, and field effect-based gas sensors. It is shown that besides step-by-step improvements of conventional principles, e.g. by the application of novel materials, novel principles turned out to enable new marke...

Alzheimer’s disease (AD) is characterized behaviourally by progressive memory and cognitive decline and physiologically by the presence of two established pathophysiological hallmarks in the brains that are extracellular accumulations of amyloidbeta peptide (Aβ) and intracellular neurofibrillar tangles of hyper phosphorylated tau protein [1,2]. Studies claimed that Aβ is generated by the sequen...

We have realised a microsystem for the culture and electrical characterisation of epithelial cell layers for cell-based diagnostic applications. The main goal of this work is to achieve both cell culture and impedimetric and potentiometric characterisation on a single device. The miniaturised cell culture system enables the uses of scarce epithelial cells, as obtained from transgenic mice or fr...

A novel impedimetric biosensor was fabricated for total cholesterol sensing based on platinum nanoparticle and polypyrrole multilayer nanocomposite electrode. The Pt nanoparticles (PtNP) electrochemically deposited between two polypyrrole layers on indium tin oxide (ITO) glass plates (PtNP/PPY/ITO) have offered high-electroactive surface area and favourable microenvironment for immobilization o...

In this article, we report on the formation and mode-of-operation of an affinity biosensor, where alternate layers of biotin/streptavidin/biotinylated-CRP-antigen/anti-CRP antibody are grown on printed gold electrodes on disposable paper-substrates. We have successfully demonstrated and detected the formation of consecutive layers of supra-molecular protein assembly using an electrical (impedim...

An impedimetric biosensor based on PEGylated arginine functionalized magnetic nanoparticles for early detection of cervical cancer is reported. The cervical cancer cells could be selectively and sensitively detected down to 10 cells mL(-1) on the modified electrode, which is promising for advancement in clinical diagnosis and monitoring of tumors.