BACKGROUND The opening and closing of the implantation window is important for successful pregnancy in eutherians. The recent study demonstrated that the window of uterine receptivity was prepared by the sole action of progesterone in mice, but the mechanism to close the window remained to be elucidated. METHODS The pregnant mice were ovariectomized on the evening on the third day of pregnanc...

Introduction: In implantation, endometrial epithelium is affected by the release of steroid hormones secreted from the ovary and allows the blastocyst to bind. This course is called the “implantation window” and occurs about 4-10 days after the onset of progesterone secretion. Therefore, the endometrium undergoes changes in the configuration of microvilli in the apical membrane, as well as the ...

The success of implantation is an interactive process between the blastocyst and the uterus. Synchronized development of embryos with uterine differentiation to a receptive state is necessary to complete pregnancy. The period of uterine receptivity for implantation is limited and referred to as the "implantation window", which is regulated by ovarian steroid hormones. Implantation process is co...

Many underlying causes of human infertility have been overcome by using in vitro fertilization (IVF) and embryo transfer (ET) techniques. Nevertheless, implantation rates in IVF programs remain low despite the transfer of apparently healthy embryos. This suggests that there are problems with the differentiation of the uterus to the receptive state in response to the ovarian hormones estrogen an...