The art of predicting the results of any drug treatment has always been a topic of interest among the scientific community across the globe. Many diseases have been attributed to gene defects, giving rise to a whole new field of pharmacogenomics within the domain of clinical pharmacology. Stratified medicine is the science of associating such diseases with genetic defects and predicting the eff...

OBJECTIVE The introduction of effective treatment strategies in the past two decades has changed the management of RA dramatically. The objective was to analyse the changes in disease activity, function, joint damage and incidence of orthopaedic surgery over a period of 20 years (1989-2009) for patients with RA. METHODS Data acquired from 1989 to 2008 inclusive from the Nijmegen RA inception ...

Experimental measurements of laser-induced ionization were performed for ethene-air premixed flames operated near the soot inception point. Soot was ionized with a pulsed laser operated at 532 nm. The ionization signal was collected with a tungsten electrode located in the postflame region. Ionization signals were collected by use of both single-electrode and dual-electrode configurations. Earl...

Discharges from shipping are estimated to account for about 20% of global discharges at sea. The protection of the marine environment can be greatly enhanced by reducing these discharges of ship generated waste and cargo residues into the sea. Achieving zero-waste in maritime transport is one of the Commission's policy goals, as set out in the Commission Communication on strategic goals and rec...