The purpose of the present study was to compare the in vitro release and to find out whether the bioavailability of a 75 mg indomethacin capsule (Microcid SR) was equivalent to optimized formulation (indomethacin-loaded cetyl alcohol microspheres). Indomethacin-loaded cetyl alcohol microspheres were prepared by meltable emulsified cooling-induced technique. Surface morphology of microspheres ha...

The chemopreventive efficacy of dehydroepiandrosterone (DHEA) and indomethacin (IM) alone or in combination was investigated in a rat multiorgan carcinogenesis model. These two chemicals were selected as chemopreventive agents with different functions. Animals were sequentially given five carcinogens with different organ target sites in the first 4-week initiation period. One week after its com...

We used electrophysiological methods in a slice preparation to study the mechanisms of somatostatin (SS) effects on hippocampal pyramidal neurons. SS hyperpolarizes hippocampal pyramidal neurons in part by augmenting the time- and voltage-dependent M-current (IM), which has been shown to be reduced by muscarinic agonists. The SS effects are abolished by the phospholipase A2 inhibitors 4-bromoph...

Indomethacin (IM), most widely used non-steroidal anti-inflammatory drug widely used in developing countries, is classified in Class II in the Biopharmaceutics Classification Systems; this means that IM has very low water solubility and high permeability, thus the dissolution is the absorption rate-limiting factor. The aim of this work was to evaluate the suitability of melt granulation techniq...

Background and Aims: Since 1980's, several preclinical studies have been published on the anti-colorectal cancer activity of nonsteroidal anti-inflammatory drug indomethacin. The direct anti-proliferative effect indomethacin seems to occur via a variety reported COX-independent mechanisms. Acemetacin is glycolic acid ester derivative contrary indomethacin, there not much research anti-cancer ef...

Acemetacin is the carboxymethyl ester of indomethacin and a pro-drug precursor compound, in other words, prodrug. The pharmacologically active metabolite acemetacin also indomethacin. exerts its potent non-steroidal anti-inflammatory effects body as It known that not only prodrug indomethacin, but an agent with gastric protective mechanisms, possibly involving reduction leukocyte adhesion, by e...

Nonsteroidal anti-inflammatory drugs (NSAIDs) can cause epithelial cell damage in the stomach, intestine, and colon. NSAIDs are reported to induce autophagy and apoptosis in intestinal epithelial cells; however, their role in cell damage is poorly understood. To examine the role of autophagy in cell damage, we used autophagy-related gene Atg5-conditional knockout mice, in which the Atg5 gene is...

BACKGROUND In this paper, a new type of physical penetration technology for transdermal administration with traditional Chinese medicine (TCM) characteristics is presented. Fu's cupping therapy (FCT), was established and studied using in vitro and in vivo experiments and the penetration effect and mechanism of FCT physical penetration technology was preliminarily discussed. METHODS With 1-(4-...

The goal of any drug delivery system is to provide a therapeutic amount of drug (s) to the proper site in the body in order to promptly achieve and thereby to maintain the desired drug concentrations during treatment. This idealized objective can be achieved by targeting the drugs to a specific organ or tissue with the help of controlling the release rate of the drug during the transit time in ...