A cohort of 169 births to women who were exposed throughout pregnancy to chloroquine 300 mg base once a week for chemosuppression of malaria was studied. The birth defects in this cohort were compared with those in a control group of 454 births to women who were not exposed to chloroquine, most of whom lived in non-malarious areas. The proportion of birth defects in the exposed group was not si...

Background & Aim: Homalium letestui Pellegr (Flacourtiaceae) used traditionally by the Ibibios of Southern Nigeria to treat stomach ulcer, malaria and other inflammatory diseases was evaluated for antiulcer properties.  Experimental: The effects of ethanol stem extract of H. letestui (200 – 600 mg/kg) and fractions (Aqueous and Dichloromethane, 400 mg/kg) on experimentally in...

Background & Aim: Homalium letestui Pellegr (Flacourtiaceae) used traditionally by the Ibibios of Southern Nigeria to treat stomach ulcer, malaria and other inflammatory diseases was evaluated for antiulcer properties.  Experimental: The effects of ethanol stem extract of H. letestui (200 – 600 mg/kg) and fractions (Aqueous and Dichloromethane, 400 mg/kg) on experimentally in...

Epidemiological observations suggest that T cell immunity may be suppressed in malaria-endemic areas. In vitro studies, animal models, and limited data in humans link immunosuppression with malaria, malnutrition, and other parasitic infections. However, there are no data to determine whether malaria-induced immunosuppression is significant in the long-term, or relative data comparing it with ot...

introduction malaria is the most important parasitic infection, which is now spread all over the globe. malaria infections with more than two species, especially plasmodium falciparum and p. vivax, are common, but infections with p. malariae and p. falciparum are rare. discussion mixed malaria infection is not uncommon, and it needs to be diagnosed and treated effectively in order to control th...

background: glucose-6-phosphate dehydrogenase (g6pd) is an x-linked enzymopathy affecting about 400 million people worldwide. neonatal jaundice, drug induced haemolysis and infection-induced haemolysis may happen in some deficient individuals and lead to considerable mortality. the distribution of g6pd deficiency and the molecular genetics of this enzyme vary widely among different ethnic group...

it has been estimated that nearly half of the world’s population is at the risk of contracting malaria with sub saharan africa being the most risky area. the existing frontline malaria control interventions are not only expensive but also become ineffective owing to the emergence of insecticide and drug resistance. it calls for an innovative approach in terms of potential and reliable vaccine a...

background & aim:zea mays leaf used traditionally in ibibio ethno medicine in southern nigeria to treat malaria and other inflammatory diseases. these anti-inflammatory and analgesic properties were evaluated against experimentally induced inflammation and pains using standard models. experimental: the effects of ethanol leaf extract of zea mays (170 -510 mg/kg) on experimentally induced inflam...

We have tested the hypothesis that activation of T cells by exposure to malaria antigens facilitates both de novo HIV infection and viral reactivation and replication. PBMC from malaria-naive HIV-uninfected European donors could be productively infected with HIV following in vitro stimulation with a lysate of Plasmodium falciparum schizonts and PBMC from malaria-naive and malaria-exposed (semi-...