Introduction: Astrocytes have an important role in many neurodegenerative diseases. Active astrocytes release inflammatory factors such as NO and ILs. Shikonin, a naphthoquinone pigment of Lithospermum erythrorhizon roots has anti-inflammatory and antitumoral effects. The present study aims to investigate the anti-inflammatory and toxic effects of Shikonin on cultured astrocytes. Methods...

a series of novel indeno[1, 2-b]quinoxalin-11-ylidenamines 2-9 have been synthesized via condensation of indane[1, 2-b]quinoxalin-11-one (1) with various primary aromatic amines in presence of acoh for 3 h. compound 1 was synthesized by condensation of indane-1,2,3-trione with benzene-1,2-diamine in presence of acoh. the synthesized compounds were characterized by ir, 1h-nmr, mass spectra and e...

background: low dose theophylline may have some anti-inflammatory effects on copd patients. this study was conducted to determine the effect of oral low dose theophylline on serum crp level in patients with stable copd. methods: in this double blind randomized clinical trail study, 50 patients (25 in experimental and 25 in placebo group) were enrolled into the study by randomized blocking metho...

introduction: nasal polyps are benign prolapsed mucosal lesions which commonly arise from the paranasal sinuses and lateral walls of the nose especially the contact areas of osteomeatal complex. though nasal polyps arising from the nasal septum have been reported, those arising from its anterior part are extremely rare and present a diagnostic dilemma.  aetiology is multifactorial and is mainly...

anti-inflammatory activity has been reported for a few of antidepressant drugs and in contrary sertraline has potentiated inflammation. in this study, anti-inflammatory effect of a collection of antidepressant drugs belonging to different classes was evaluated to help a rational selection of these drugs in disease conditions such as association of depression or anxiety with inflammatory disease...

introduction: knee osteoarthrosis is one of the most debilitating diseases. prolotherapy includes intraarticular injection of various drugs to decrease inflammation. injection of intradiscal o2-o3 has reduced pain and disability of patients with low back pain due to prolapsed lumbar disk. objective: to compare the effect of intraarticular injection of ozone and steroids in improvement of clinic...

background : there is an association   of celiac disease (cd) with several gastrointestinal illnesses. we aimed to determine   the prevalence of cd in patients with inflammatory bowel disease (ibd) to evaluate the value of the routine serological tests for cd in these patients. methods : patients with ibd underwent   screening test for cd. the screening test was based on iga anti-ttg antibody e...