influenza c virus possesses specific neuraminate-o-acetylesterase as a receptor-destroying function. this enzymatic activity of the viral glycoprotein hef (hemagglutinin, esterase activity and fusion factor) can be visualized in situ by the use of distinct color substrates. hereby the localization, as well as the quantity of synthesized hef protein is detectable. we further developed the estera...

respiratory virus infection is a major cause of asthma exacerbation. however, the underlying mechanisms of  this exacerbation  are unknown. therefore,  to  determine  the mechanisms, we examined the effect of influenza infection in a murine model of asthma.mice were divided into four groups: the phosphate-buffered saline (pbs), house dust mite (hdm), influenza, and hdm/influenza groups. the inf...

objective: the use of bacterial plasmids carrying specific genes of pathogens as genetic vaccines is a relatively new technique for induction of cellular immune responses against microbial pathogens. mechanisms of production of specific immune responses against these vaccines are not still completely understood. therefore, it is necessary to examine various routes of inoculation to find the bes...

background: influenza virus is the major cause of lower respiratory tract illnesses on the worldwide. vaccination can be an effective tool to prevent its outbreak. highly conserved viral nucleoprotein is an effective vaccine candidate to provide heterosubtypic immunity, offering resistance against various influenza virus strains. m aterials and methods: in present research np gene was inserted ...

High morbidity and mortality of influenza virus infection makes it an important disease world-wide. Mouse is a very well-studied animal model for this disease with similar manifestation to human disease. It would be desirable to induce mucosal as well as circulating immune responses to obtain protection from infection and to decrease the spread of the virus. Cell mediated immunity (proliferativ...

results: of 655 samples, 69 (10.53%) had positive results for human influenza a virus, and 5 (0.7%) samples had positive results for influenza b. of those 69 samples with positive results for influenza a viruses, 45 (6.8%) were h3n2, and 24 (3.6%) were h1n1 subtypes. in this study most cases with positive results were less than 20 years. the sample positive included 49% males and 51% females. t...

Fifteen strains of influenza C virus were isolated from abattoir pigs in China in 1981 and antibody against influenza C virus was found in pig sera. Virus survey also showed seasonal activity of influenza C virus in pigs. Additionally, experimental infection of pigs with influenza C virus demonstrated that Chinese domestic pigs could be infected by influenza C virus and that the virus could be ...

Dear Editor-in-Chief, Influenza, commonly known as the flu, is an infectious disease caused by an influenza virus (1). Symptoms can be mild to severe (2). The most common symptoms include: high fever, runny nose, sore throat, muscle pains, headache, coughing, sneezing, and feeling tired (1). Three of the four types of influenza viruses affect people, Type A, Type B, and Type C (3, 4). Type D ha...

objective this is the first report of cns involvement by the new influenza virus (influenza a [h1n1]) in iran. the patient was a 10-year-old boy with chief complaints of fever, malaise, and cranial nerve involvement, resulting in respiratory muscle paralysis and intubation. this shows that the new influenza virus, as well as the seasonal flu, can cause neurologic complications; however, the sev...