نتایج جستجو برای: informative dropout

تعداد نتایج: 31950  

Journal: :Journal of probability and statistics 2012
Mengling Liu Wenbin Lu

We propose a marginalized joint-modeling approach for marginal inference on the association between longitudinal responses and covariates when longitudinal measurements are subject to informative dropouts. The proposed model is motivated by the idea of linking longitudinal responses and dropout times by latent variables while focusing on marginal inferences. We develop a simple inference proced...

Journal: :Biometrics 2004
Joseph W Hogan Xihong Lin Benjamin Herman

The analysis of longitudinal repeated measures data is frequently complicated by missing data due to informative dropout. We describe a mixture model for joint distribution for longitudinal repeated measures, where the dropout distribution may be continuous and the dependence between response and dropout is semiparametric. Specifically, we assume that responses follow a varying coefficient rand...

Journal: :Journal of biopharmaceutical statistics 2000
M W Ali O Siddiqui

Statistical analysis based on multiple imputation (MI) of missing data when analyzing data with missing observations is gaining popularity among statisticians because of availability of computing softwares; it might be tempting to use MI whenever data is missing. An important assumption behind MI is the "ignorability of missingness." In this paper, we demonstrate the use of MI in conjunction wi...

2010
Li Su Joseph W. Hogan

Dropout is a common occurrence in longitudinal studies. Building upon the pattern-mixture modeling approach within the Bayesian paradigm, we propose a general framework of varying-coefficient models for longitudinal data with informative dropout, where measurement times can be irregular and dropout can occur at any point in continuous time (not just at observation times) together with administr...

Journal: :The Stata Journal: Promoting communications on statistics and Stata 2010

2013
Ruwanthi Kolamunnage-Dona Colin Powel Paula Williamson

In many clinical trials with longitudinal outcome data, a common situation is where some patients withdraw or dropout from the trial before completing the measurement schedule. In most cases reasons for dropout is related to the subsequent outcome, hence missingess is informative or non-ignorable. Failure to take appropriate account of such missing data can lead to biased estimation of treatmen...

Journal: :European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2013
Navin Goyal Roberto Gomeni

Dropouts impact clinical trial outcome analyses. Ignoring missing data is not an acceptable option when planning, conducting or interpreting the analysis of a clinical trial. Treatment related efficacy and safety data observed in the trial may not always be sufficient in explaining the dropouts' mechanism. Nevertheless, these dropout data may carry important treatment-related information and pr...

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