The INLA approach for approximate Bayesian inference for latent Gaussian models has been shown to give fast and accurate estimates of posterior marginals and also to be a valuable tool in practice via the R-package R-INLA. In this paper we formalize new developments in the R-INLA package and show how these features greatly extend the scope of models that can be analyzed by this interface. We al...

Intestinal Listeria monocytogenes infection is not efficient in mice and this has been attributed to a low affinity interaction between the bacterial surface protein InlA and E-cadherin on murine intestinal epithelial cells. Previous studies using either transgenic mice expressing human E-cadherin or mouse-adapted L. monocytogenes expressing a modified InlA protein (InlA(m)) with high affinity ...

The integrated nested Laplace approximation (INLA) is a deterministic approach to Bayesian inference on latent Gaussian models (LGMs) and focuses fast accurate of posterior marginals for the parameters in models. Recently, methods have been developed extend this class those that can be expressed as conditional LGMs by fixing some descriptive values. These differ manner values are chosen. This a...

Integrated nested Laplace approximations (INLA) are a recently proposed approximate Bayesian approach to fit structured additive regression models with latent Gaussian field. INLA method, as an alternative to Markov chain Monte Carlo techniques, provides accurate approximations to estimate posterior marginals and avoid time-consuming sampling. We show here that two classical nonparametric smoot...

We report a study of the interaction between internalin A (inlA) and human or murine E-cadherin (Ecad). inlA is used by Listeria monocytogenes to internalize itself into host cell, but the bacterium is unable to invade murine cells, which has been attributed to the difference in sequence between hEcad and mEcad. Using molecular dynamics simulations, MM/GBSA free energy calculations, hydrogen bo...

Fourteen human carriage Listeria monocytogenes isolates were compared to sporadic and epidemic-associated human strains in order to ascertain the pathogenic behavior of these unrecognized asymptomatic strains. Experimental infection of 14-day-old chick embryos revealed that the majority of the carriage strains were attenuated for virulence. Of the 10 attenuated carriage strains, 5 were affected...

Epidemiological studies have provided considerable evidence that Listeria monocytogenes trains differ in their ability and relative likelihood to caus~ human disease. Multiple mutations leading to premature stop codons (PMSCs) have been identified in the key L. monocytogenes virulence gene inIA, which codes for a surface protein that mediates the entry of L. monocytogenes into host cells. Mutat...

Listeria monocytogenes produces severe fetoplacental infections in humans. How it targets and crosses the maternofetal barrier is unknown. We used immunohistochemistry to examine the location of L. monocytogenes in placental and amniotic tissue samples obtained from women with fetoplacental listeriosis. The results raised the possibility that L. monocytogenes crosses the maternofetal barrier th...

Animal models are generalized linear mixed models used in evolutionary biology and animal breeding to identify the genetic part of traits. Integrated Nested Laplace Approximation (INLA) is a methodology for making fast, nonsampling-based Bayesian inference for hierarchical Gaussian Markov models. In this article, we demonstrate that the INLA methodology can be used for many versions of Bayesian...

Recently we have successfully exploited and applied the new and powerful non-parametric Integrated Nested Laplace Approximation (INLA) Bayesian inference method to the problem of Superresolution (SR) image reconstruction, generating the INLA SR algorithm. Even though achieving superior image reconstruction results in comparison to other state-of-the-art methods, such algorithm manipulates matri...