introduction  insulin-like growth factor i (igf-i) which is produced in abundance in the normal adult liver, is deeply involved in hepatocyte survival, growth, and differentiation during liver development. igf-i plays the roles via the receptor (igf-ir) signaling pathway. igf-ir unlike igf-i is expressed strongly in the developing liver, but much more weakly in adults. objective:  we hypothesiz...

introduction: adenotonsillar hypertrophy (ath) may present with growth retardation. insulin-like growth factor 1 (igf-1) mediates the anabolic effects of growth hormone (gh) on tissues. most of the circulating igf-1 molecules are bound to insulin-like growth factor-binding protein 3 (igfbp-3). igf-1 and igfbp-3 serum levels reflect the levels of daily mean serum gh and are used as indices for e...

Insulin-like growth factors and insulin are phylogenetically closely related polypeptides and have many structural and biological similarities. Low levels of circulating insulin-like growth factor-I (IGF-I), diabetes and insulin resistance have all been implicated in the pathogenesis of cardiovascular disease, but the mechanisms involved are still not clear. Furthermore little is known about di...

A defined culture medium containing insulin, insulin-like growth factor I (IGF-I) or insulin-like growth factor II (IGF-II) supported morphological development of myenteric plexus neurons derived from neonatal guinea pigs. Insulin increased neurite outgrowth 3-fold at concentrations as low as 0.2 nM. Similar significant and dose-dependent increases in neurite outgrowth were noted with IGF-I and...

Insulin-like growth factor (IGF) remains in the different classes of vertebrates including birds [1,2], reptiles, amphibians [3], fishes [4-6] and mammals [7]. Insulin-like growth factor I (IGF-I) is a protein comprising two major forms, IGF-I and IGF-II [8,9] . The IGF-I is produced from the liver Sjogren et al. [10] by the influence of growth hormone involving the axis of pituitary/hepatic sy...

background: the aim of this study was to evaluate whether higher serum levels of insulin-like growth factor-i (igf-i) in the acute phase of ischemic stroke are associated with less severe strokes and better functional outcome in a period of 12-month follow-up. methods: from october 2014 to august 2015, patients with the diagnosis of acute ischemic stroke admitted to the stroke unit of firoozgar...

background a fall in plasma concentration of energy status related hormones (leptin, insulin-like growth factor-1 (igf-1) and insulin) and body energy expenditure occurs in response to short term fasting. nevertheless, the relations of the fasting-induced changes in energy related hormones and metabolites with fasting energy expenditure (fee) under extended fasting condition have received littl...