The interaction of hGH with some metal ions ( ) at 27°C in NaC1 solution, 50 mM was studied using Isothermal titration calorimetry. There is a set of three identical and non-interacting binding sites for binding of all these metal ions, expect . The intrinsic association equilibrium constants () are not very different for  and , and also their molar enthalpies of binding (KJ/mol for  and  KJ/mo...

Physical interactions between proteins are important for many cellular functions. Since protein-protein interactions are mediated via their interaction sites, identifying these interaction sites can therefore help to discover genome-scale protein interaction map, thereby leading to a better understanding of the organization of living cell. To date, the experimentally solved protein interaction ...

Wnts are the major ligands responsible for activating Wnt signaling pathway through binding to Frizzled proteins (Fzd) as the receptors. Among these ligands, Wnt2 plays the main role in the tumorigenesis of several human cancers especially colorectal cancer (CRC). Therefore, it can be considered as a potential drug target.The aim of this study was to identify potential drug candidates ...

Wnts are the major ligands responsible for activating Wnt signaling pathway through binding to Frizzled proteins (Fzd) as the receptors. Among these ligands, Wnt2 plays the main role in the tumorigenesis of several human cancers especially colorectal cancer (CRC). Therefore, it can be considered as a potential drug target.The aim of this study was to identify potential drug candidates ...

We describe an approach for computational prediction of protein-protein interaction sites using a support vector machine (SVM) classifier. Interface residues and other surface residues were extracted from 115 proteins derived from a set of 70 heterocomplexes in PDB. The SVM classifier was trained to predict whether or not a surface residue is located in the interface based on the identity of th...